Fat Metabolism in Response to Acute Diet- and Exercise-induced Changes in Energy Balance

NCT00830999 | Completed DMC

• 1 other identifier: 05-0195
• Study Type: interventional
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

This study is being conducted to learn more about the role of diet and exercise in regulating plasma triglyceride (fat) metabolism. The investigators will examine the effect of acute (24 hour) changes in energy intake and expenditure on fat metabolism the following day.

Conditions

Cardiovascular Diseases

Keywords

fat metabolism; exercise; liver; lipoproteins; triglycerides

Outcome Measures

Primary Outcomes (1)

• Very Low Density Lipoprotein-Triglyceride and apoB-100 concentrations

  After acute (24 hour) changes in energy intake and/or energy expenditure

Secondary Outcomes (8)

• Liver Very Low Density Lipoprotein-Triglyceride and apoB-100 secretion rates

  After acute (24 hour) changes in energy intake and/or energy expenditure

• Liver Very Low Density Lipoprotein-Triglyceride and apoB-100 clearance rates from plasma

  After acute (24 hour) changes in energy intake and/or energy expenditure

• Plasma glucose concentration and turnover rate

  After acute (24 hour) changes in energy intake and/or energy expenditure

• Plasma insulin concentration

  After acute (24 hour) changes in energy intake and/or energy expenditure

• Plasma free fatty acid concentration and turnover rate

  After acute (24 hour) changes in energy intake and/or energy expenditure

Study Arms (4)

Positive energy balance

EXPERIMENTAL

Comparison between isocaloric and hypercaloric diets with no exercise performed in any trials

Behavioral: Positive energy balance; Behavioral: Energy balance

Energy balance with exercise

EXPERIMENTAL

Comparison between an isocaloric diet without exercise and a hypercaloric diet with a sufficient amount of exercise performed to match the excess calories consumed resulting in both trials being in net energy balance.

Behavioral: Energy balance with exercise; Behavioral: Energy balance

Negative energy balance

EXPERIMENTAL

Comparison between isocaloric and hypocaloric diets with no exercise performed in any trials

Behavioral: Negative energy balance; Behavioral: Energy balance

Negative energy balance with exercise

EXPERIMENTAL

Comparison between consuming an isocaloric diet without exercise and consuming the same amount of calories as in the isocaloric trial but with exercise performed resulting in net negative energy balance in the exercise trial.

Behavioral: Negative energy balance with exercise; Behavioral: Energy balance

Interventions

Positive energy balance BEHAVIORAL

Subjects will consume over a 24 hour period 33% more calories than they require to meet their energy demands.

Positive energy balance

Energy balance with exercise BEHAVIORAL

Subjects will consume over a 24 hour period 33% more calories than they require to meet their energy demands but will perform 2 hours of exercise that will be sufficient to burn off the excess calories consumed resulting in subjects being in net energy balance.

Energy balance with exercise

Negative energy balance BEHAVIORAL

Subjects will consume over a 24 h period only 66% of the calories required to meet their energy demands such that they will be in a net negative calorie balance in this trial.

Negative energy balance

Negative energy balance with exercise BEHAVIORAL

Subjects will consume over a 24 hour period the same amount of calories as ingested in the isocaloric trial but will also perform 2 hours of exercise that will be sufficient to burn off a third of the calories they consumed during this day resulting in subjects being in net negative energy balance in this trial

Negative energy balance with exercise

Energy balance BEHAVIORAL

Subjects will consume over a 24 hour period a sufficient amount of calories to meet their energy needs.

Energy balance with exercise; Negative energy balance; Negative energy balance with exercise; Positive energy balance

Eligibility Criteria

• Age: 21 Years - 50 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• overweight and obese men
• normal to mild hypertriglyceridemia

You may not qualify if:

• Smoking
• Any medical condition other than increased body weight (e.g. diabetes, heart disease, etc.).
• Use of drugs known to affect lipid metabolism (e.g. statins, etc.).
• Regular exercise training.

Sponsors & Collaborators

• Washington University School of Medicine: lead

Study Sites (1)

Washington University in Saint Louis

St Louis, Missouri, 63110, United States

Location

Related Publications (1)

• Smith GI, Magkos F, Reeds DN, Okunade AL, Patterson BW, Mittendorfer B. One day of mixed meal overfeeding reduces hepatic insulin sensitivity and increases VLDL particle but not VLDL-triglyceride secretion in overweight and obese men. J Clin Endocrinol Metab. 2013 Aug;98(8):3454-62. doi: 10.1210/jc.2013-1786. Epub 2013 Jun 7.

  PMID: 23750033 DERIVED

MeSH Terms

Conditions

Cardiovascular Diseases; Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Bettina Mittendorfer, PhD

  Washington University School of Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 26, 2009
• First Posted: January 28, 2009
• Study Start: April 1, 2006
• Primary Completion: December 1, 2012
• Study Completion: December 1, 2012
• Last Updated: January 21, 2013

Record last verified: 2013-01

Locations

US (1)