NCT00829855|CompletedDMC
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Sponsor study identifier
Secondary identifiers
observational
51
1 country
1
Study Start
May 2008
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
May 2009
Actual (reported)Study Completion
May 2009
Actual (reported)Acute cardiogenic pulmonary edema (ACPE), one of the most severe forms of acute heart failure, represents 5% of hospital admissions. One of the most frequent phenomena encountered during ACPE is hypertensive crisis (hypertensive ACPE) but the mechanisms and causes of hypertensive ACPE are insufficiently understood. Few studies have evaluated the cardiac function during hypertensive ACPE, and these studies used only conventional echocardiography methods. New methods of evaluation of cardiac function in hypertensive ACPE (such as Tissue Doppler imaging) have not been used. The objectives of this study are to evaluate presence and role of the following potential mechanisms of hypertensive ACPE: 1. acute myocardial dysfunction (systolic and diastolic); 2. silent transient myocardial ischemia; 3. acute mechanical left ventricular dyssynchrony; 4. dynamic mitral regurgitation; 5. inter-ventricular interaction. Conventional and Tissue Doppler echocardiography will be used to assess cardiac function.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
May 2009
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
May 2008
Date type not reportedThis date has not been verified as actual or estimated.
January 26, 2009
Actual (reported)January 27, 2009
Actual (reported)May 2009
Actual (reported)May 2009
Actual (reported)acute myocardial dysfunction (systolic and diastolic) and/or dyssynchrony
acute event and 48 to 96 h after the event
surrogate markers of silent transient myocardial ischemia
acute event and 48 to 96 h after the event
dynamic mitral regurgitation
acute event and 48 to 96 h after the event
inter-ventricular interaction
acute event and 48 to 96h after the event
Patients with hypertensive (systolic blood pressure ≥160 mmHg) acute pulmonary edema, evaluated within 120 minutes after admittance.
The same patients from group 1 followed-up at 48 to 96 hours.
Patients admitted in the Cardiac Care Unit of an University and Emergency Hospital, with a diagnosis of acute cardiogenic pulmonary edema associated with hypertension (systolic blood pressure ≥160 mmHg)
Department of Cardiology, University and Emergency Hospital of Bucharest
Bucharest, 050098, Romania
Mircea Cinteza, MD, PhD
University of Medicine and Pharmacy "Carol Davila" Bucharest
Dragos Vinereanu, MD, PhD
University of Medicine and Pharmacy "Carol Davila" Bucharest
Andrei D Margulescu, MD
University of Medicine and Pharmacy "Carol Davila" Bucharest
51 participants (actual enrollment reported by the registry).
First Submitted
January 26, 2009
First Posted
January 27, 2009
Study Start
May 2008
Date type not reportedThis date has not been verified as actual or estimated.
The Blood Pressure and Metabolic Effects of Nebivolol in Hypertensive Patients With Impaired Glucose Tolerance or Impaired Fasting Glucose
Contact the study team to confirm eligibility.
Primary Completion
May 2009
Actual (reported)Study Completion
May 2009
Actual (reported)Last Updated
March 5, 2013
Record last verified: 2013-03
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Source: ClinicalTrials.gov.
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