Multimodal Treatment of Phonological Alexia: Behavioral & fMRI Outcomes

NCT00827268 | Completed

• 1 other identifier: B6699-W
• Study Type: interventional
• Target: 5
• Locations: 1 country
• Sites: 1

Brief Summary

This study offers 90-120 hours of 1:1 training to improve reading skills in adults who have poor reading skills following a stroke. Specifically, this study is designed to improve skill in sounding out words for reading and spelling. The overall time commitment for participation in this study is approximately 11-30 weeks.

Conditions

Aphasia; Stroke; Dyslexia, Acquired

Keywords

Dyslexia; Reading; Aphasia; Stroke

Outcome Measures

Primary Outcomes (1)

• Change in Real World Reading Skills

  Real World Reading Skills was tested using the Woodcock Reading Mastery Test-Revised

  Language testing are conducted two weeks prior to treatment, immediately following end of treatment and 3 months after end of treatment.

Study Arms (1)

Arm 1

OTHER

Repeated probes every 8 hours of treatment (1/week)

Behavioral: One-on-one treatment of reading difficulties

Interventions

One-on-one treatment of reading difficulties BEHAVIORAL

Multimodal behavioral treatment focused on retraining sound to letter associations and skills in sounding out words when reading. Treatment has been pilot-tested in published papers since 1998.

Arm 1

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults with post-stroke reading difficulties (phonological alexia)
• \>3 months post-stroke
• native English speaker
• can go in MRI scanner (3 to 6 scans),
• participate in 90 to 120 free treatment sessions
• return for 3-month post-treatment follow-up assessment \& MRI.

You may not qualify if:

• mental illness
• degenerative disease, visual or auditory acuity impairment
• drug abuse
• English is not first language
• claustrophobia
• pregnancy

Sponsors & Collaborators

• VA Office of Research and Development: lead

Study Sites (1)

North Florida/South Georgia Veterans Health System

Gainesville, Florida, 32608, United States

Location

Related Links

• Dr. Conway's homepage

MeSH Terms

Conditions

Aphasia; Stroke; Dyslexia, Acquired; Dyslexia

Condition Hierarchy (Ancestors)

Speech Disorders; Language Disorders; Communication Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Specific Learning Disorder; Learning Disabilities; Neurocognitive Disorders; Mental Disorders; Neurodevelopmental Disorders

Study Officials

• Timothy W. Conway, PhD

  North Florida/South Georgia Veterans Health System

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: FED
• Responsible Party: SPONSOR

Model Details: This is a repeated probe design study.

Study Record Dates

• First Submitted: January 20, 2009
• First Posted: January 22, 2009
• Study Start: June 1, 2009
• Primary Completion: December 1, 2011
• Study Completion: July 1, 2012
• Last Updated: November 30, 2017

Record last verified: 2017-11

Locations

US (1)