NCT00823758

Brief Summary

Introduction to Study Objectives: In a joint collaboration of the Centers for Education and Research on Therapeutics (CERTS) at The University of Pennsylvania and the M.D. Anderson Cancer Center, this study proposes to a) combine detailed but under-utilized existing large datasets and b) collect new primary data; together, resulting two data resources will advance our ability to describe, study, and understand the effectiveness and safety of pharmaceuticals received by pediatric patients in hospitals, and how to improve the safe use of over-the-counter (OTC) acetaminophen in home settings. The CERTS study is organized into two projects: Project I and Project II. For this protocol, the study focus will be Project II-Phase 1. Project II will seek to qualitatively describe the patterns of use and misuse of over-the-counter OTC acetaminophen, through information gathered from consumers of various age groups, as well as professional key informants. Project II-Phase 1 Objective 1:

  • Qualitatively explore knowledge, attitudes, beliefs, and practices regarding adult and adolescent self-administration of OTC acetaminophen, and parental administration of OTC acetaminophen to children. Objective 2:
  • Qualitatively explore experiences and practices of key professional informants, including physician and pharmacists, with respect to communicating information on the administration and risks of OTC acetaminophen to consumers and patients.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
124

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Dec 2008

Longer than P75 for all trials

Geographic Reach
1 country

4 active sites

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 19, 2008

Completed
27 days until next milestone

First Submitted

Initial submission to the registry

January 15, 2009

Completed
1 day until next milestone

First Posted

Study publicly available on registry

January 16, 2009

Completed
11.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2020

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2020

Completed
Last Updated

January 27, 2020

Status Verified

January 1, 2020

Enrollment Period

12 years

First QC Date

January 15, 2009

Last Update Submit

January 24, 2020

Conditions

Keywords

AcetaminophenLiverCenters for Education and Research on TherapeuticsCERTSOver-the-counter AcetaminophenOTCSelf-administrationParental administrationHoustonTexasLiver toxicityQualitative studyPharmacistsAdolescentsPrimary care physiciansFamily PractitionersGeneral Internist

Outcome Measures

Primary Outcomes (1)

  • Qualitatively Described Patterns of Use + Misuse of Over-the-counter (OTC) Acetaminophen

    1 Year

Study Arms (5)

1

Parents of children under 8 years of age who have ever given their children an over- the-counter medication.

Behavioral: Focus Groups

2

Adolescents who are 13 to 20 years of age who have ever heard of over-the-counter medication.

Behavioral: Personal Interviews

3

Adults (21 years of age or older) who have used over-the-counter medication in the past 2 years.

Behavioral: Focus Groups

4

Primary care physicians will be Family Practitioners or General Internist, with an active Texas license, who devote at least 50% of their time to clinical practice.

Behavioral: Focus Groups

5

Pharmacists holding a PharmD degree and licensure in the state of Texas and work at least half-time in a community pharmacy setting.

Behavioral: Focus Groups

Interventions

Focus GroupsBEHAVIORAL

6 to 8 participants per group.

1345

Conducted by phone and audiotaped.

2

Eligibility Criteria

Age13 Years+
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Parents of young children (8 years of age or younger) who administered acetaminophen to their children, Adults and Adolescents (aged 13-20 years of age) familiar with or used OTC acetaminophen in the last 2 years, and Primary care physicians and Pharmacists. All Houston, Texas residents.

You may qualify if:

  • English or Spanish language proficiency.
  • Residence in Metropolitan Houston, Texas.
  • Adequate cognition as determined by the research staff through the use of questions related to orientation about person, time and place.
  • Adolescents who are 13 to 20 years of age who have ever heard of over-the-counter medication (We will recruit 20 adolescents through their parents, who will be required to give consent before the study staff contacts the child);or parents of children (either a mother or a father, but only one parent per family) under 8 years of age who have ever given their children an over- the-counter medication; or adults (21 years of age or older) who have used over-the-counter medication in the past 2 years.
  • Primary care physicians will be Family Practitioners or General Internist, with an active Texas license, who devote at least 50% of their time to clinical practice.
  • Pharmacists will hold a PharmD degree and licensure in the state of Texas and work at least half-time in a community pharmacy setting.

You may not qualify if:

  • Participants who do not give informed consent.
  • A parent whose spouse/partner is/has already participated in the focus group.
  • Pharmacists actively enrolled in a training program.
  • Physicians who are participating in a fellowship or residency training program.
  • Children who may be depressed or at risk of suicide or managing that risk.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (4)

The Children's Hospital of Philadelphia, University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States

Location

Baylor College of Medicine

Houston, Texas, 77030, United States

Location

Harris County Hospital District Outpatient Clinics

Houston, Texas, 77030, United States

Location

Kelsey Seybold

Houston, Texas, 77030, United States

Location

Related Links

MeSH Terms

Conditions

Liver Failure

Interventions

Focus Groups

Condition Hierarchy (Ancestors)

Hepatic InsufficiencyLiver DiseasesDigestive System Diseases

Intervention Hierarchy (Ancestors)

Data CollectionEpidemiologic MethodsInvestigative TechniquesHealth Care Evaluation MechanismsQuality of Health CareHealth Care Quality, Access, and EvaluationPublic HealthEnvironment and Public Health

Study Officials

  • Maria Suarez-Almazor, MD, PhD

    M.D. Anderson Cancer Center

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 15, 2009

First Posted

January 16, 2009

Study Start

December 19, 2008

Primary Completion

December 1, 2020

Study Completion

December 1, 2020

Last Updated

January 27, 2020

Record last verified: 2020-01

Locations