The Effect of Radioactive Iodine Administration for Thyroid Diseases on H.Pylori Eradication

NCT00822289 | Unknown

• 1 other identifier: 5071
• Study Type: observational
• Target: 120
• Locations: 0 countries
• Sites: N/A

Brief Summary

Because of the high iodine uptake in the stomach, radioactive iodine treatment for thyroid diseases (cancer or hyperthyroidism) or radioactive iodine administered for thyroid scan may be able to eradicate H.pylori infection from the stomach of patients infected with H.pylori. Also to test the hypothesis that CagA virulent strains of H.pylori are more common in patients with thyroid cancer than with other thyroid diseases.

Conditions

Helicobacter Pylori Infected Patients; Thyroid Cancer Patients; Hyperthyroidism

Keywords

radioactive iodine; Helicobacter pylori; Thyroid diseases; CagA

Outcome Measures

Secondary Outcomes (1)

• To determine whether CagA helicobacter pylori infection is more prevalent in patients with thyroid diseases compared to other thyroid diseases

  2 years

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Consecutive patients with thyroid diseases referred to the Isotopic Institute at the Rabin Medical Center, Campus Beilinson for either radioactive iodine (131I) thyroid scan or radioactive iodine (131I)treatment for their disease, will be tested, prior to the radioactive iodine, for H. pylori infection and CagA protein by serology. Patient with positive serology for H. pylori will be tested for active gastric infection using the H.pylori stool antigen test. The study population will include all patients who tested positive for H.pylori both on serology and stool antigen tests. Six to eight weeks and 6 month after administration of radioactive iodine (131I) , stool antigen or H.pylori will be tested again to confirm persistence of H.pylori eradication.

You may qualify if:

• Adult patients between the ages of 18 and 80.
• Patients with diagnosed thyroid disease referred for thyroid scan or treatment with radioactive iodine (131I).
• Patients who provide informed consent

You may not qualify if:

• Patients without diagnosed thyroid disease.
• Patients who are pregnant or breast feeding.
• Patients who have received previous treatment for H. pylori infection.
• Patients taking proton pump inhibitors.
• Patients with recent or current use of antibiotics.
• Patients allergic to iodine (131I).

Sponsors & Collaborators

• Rabin Medical Center: lead

MeSH Terms

Conditions

Hyperthyroidism; Thyroid Diseases

Condition Hierarchy (Ancestors)

Endocrine System Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: January 13, 2009
• First Posted: January 14, 2009
• Study Start: February 1, 2009
• Last Updated: January 14, 2009

Record last verified: 2009-01