Improvement of Language Disturbances After Stroke by Intensive Training and Electrical Brain Stimulation
Improvement of Aphasia After Stroke by Intensive Training and Transcranial Direct Current Stimulation
1 other identifier
interventional
20
1 country
1
Brief Summary
The study aims to identify if intensive language training, consisting mainly of computer-based object naming, together with electrical brain stimulation, will lead to an improvement of language functions in patients that suffer from language disturbances after a stroke.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for phase_2
Started Jan 2009
Shorter than P25 for phase_2
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2009
CompletedFirst Submitted
Initial submission to the registry
January 13, 2009
CompletedFirst Posted
Study publicly available on registry
January 14, 2009
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2009
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2009
CompletedJanuary 14, 2009
January 1, 2009
11 months
January 13, 2009
January 13, 2009
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Number of words correctly named after training plus tDCS
1 year
Secondary Outcomes (1)
Communicative-Activity-Log & Stroke-and-Aphasia-Quality-of-Life-Scale
1 year
Study Arms (3)
anodal tDCS
EXPERIMENTAL2
ACTIVE COMPARATORcathodal tDCS
3
PLACEBO COMPARATORsham stimulation
Interventions
Eligibility Criteria
You may qualify if:
- chronic stroke (\> 1 year after event)
- aphasia due to stroke with naming impairment
- German as first language
- first-ever stroke
You may not qualify if:
- more than 1 stroke
- progressive stroke
- history of severe alcohol or drug abuse, psychiatric illnessess like severe depression, poor motivational capacity
- dementia
- contraindications for Magnetic Resonance Imaging
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Department of Neurology, University of Muenster; Department of Neurology, University of Berlin
Muenster / Berlin, NRW/Berlin-Brandenburg, 48129/10098, Germany
Related Publications (1)
Floel A, Meinzer M, Kirstein R, Nijhof S, Deppe M, Knecht S, Breitenstein C. Short-term anomia training and electrical brain stimulation. Stroke. 2011 Jul;42(7):2065-7. doi: 10.1161/STROKEAHA.110.609032. Epub 2011 Jun 2.
PMID: 21636820DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Agnes Floel, MD
Department of Neurology, University of Muenster; Department of Neurology, University of Berlin, Germany
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- phase 2
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
January 13, 2009
First Posted
January 14, 2009
Study Start
January 1, 2009
Primary Completion
December 1, 2009
Study Completion
December 1, 2009
Last Updated
January 14, 2009
Record last verified: 2009-01