Exercise Training in Asthma

NCT00820716 | Terminated

• 2 other identifiers: 38252006-A00090-51
• Study Type: interventional
• Target: 2
• Locations: 1 country
• Sites: 2

Brief Summary

The aim of the study is to compare two methods of exercise training: alternate load versus constant load realized at moderate or high intensities, in order to define the interests and the limits of each one of these two methods. The finality is to make possible to the expert to choose what exercise training induces the best results quickly and to make its choice according to the therapeutic objectives which it lays down.We also evaluate the effects of these exercises training on the vagal response and the bronchial tone of the asthmatics. From a clinical point of view, a close attention will be paid to the effects of these exercises training on the control of asthma and the quality of life of the subjects

Conditions

Asthma

Keywords

Asthma; Asthmatic subjects; Exercise training; Constant load; Alternate load

Outcome Measures

Primary Outcomes (2)

• Maximal oxygen consumption (VO2max)

  At T-1 = eight weeks before training - At T0 = beginning of training - At T1 = eight weeks after training

• Maximal power output (Pmax)

  At T-1 = eight weeks before training - At T0 = beginning of training - At T1 = eight weeks after training

Secondary Outcomes (3)

• Exhaled NO (eNO)

  At T-1 = eight weeks before training - At T0 = beginning of training - At T1 = eight weeks after training

• Heart rate variability

  At T-1 = eight weeks before training - At T0 = beginning of training - At T1 = eight weeks after training

• Force Expiratory Volume in one second (FEV1)

  At T-1 = eight weeks before training - At T0 = beginning of training - At T1 = eight weeks after training

Study Arms (2)

CA

EXPERIMENTAL

Exercise training with alternate load

Other: Exercise training

CC

ACTIVE COMPARATOR

Exercise training with constant load

Other: Exercise training

Interventions

Exercise training OTHER

Comparison of two methods of exercise training: alternate load versus constant load realized at moderate or high intensities

CA; CC

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• to 45 years old
• mild to moderate persistent asthma (GINA classification)
• stabilized asthma
• physical activity level between 5 and 11 (Baecke and coll, 1982)
• no contra-indication for physical training

You may not qualify if:

• cardiovascular pathology
• metabolic pathology
• traumatic pathology
• BMI≥30
• tobacco
• diabetes

Sponsors & Collaborators

• University Hospital, Strasbourg, France: lead

Study Sites (2)

Service de Physiologie et d'Explorations Fonctionnelles - Pôle de Pathologie Thoracique - Nouvel Hôpital Civil

Strasbourg, 67 091, France

Location

Service de Pneumologie - Pôle de Pathologie Thoracique - Nouvel Hôpital Civil

Strasbourg, 67091, France

Location

MeSH Terms

Conditions

Asthma

Interventions

Exercise

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Evelyne LONSDORFER, MD

  Hôpitaux Universitaires de Strasbourg

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 9, 2009
• First Posted: January 12, 2009
• Study Start: September 21, 2009
• Primary Completion: October 15, 2010
• Study Completion: October 15, 2010
• Last Updated: July 14, 2020

Record last verified: 2011-08

Locations

FR (2)