Multi-centre, Long-term Comparative Trial of High Frequency Chest Wall Oscillation Versus Positive Expiratory Pressure Mask in the Treatment of Cystic Fibrosis
Sponsor study identifier
Secondary identifiers
interventional
107
1 country
13
Study Start
October 2008
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
April 2012
Actual (reported)Study Completion
July 2012
Actual (reported)This study is a preliminary study designed to determine the safety and effectiveness of HFCWO using the InCourage vest system as an airway clearance technique for the treatment of CF. The study will compare HFCWO to the most commonly used airway clearance technique in Canada, namely the Positive Expiratory Pressure technique in patients with CF over a period of one year. As this is a preliminary study, it will not be able to determine if the vest is equivelant to PEP, but will provide the information needed to plan a larger study to answer that question.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
July 2012
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
October 2008
Date type not reportedThis date has not been verified as actual or estimated.
January 2, 2009
Actual (reported)January 6, 2009
Actual (reported)April 2012
Actual (reported)July 2012
Actual (reported)Difference in the number of respiratory exacerbations during the 1 year study period
1 year
The time to the first respiratory exacerbation. Change in FEV1 measured as difference in the yearly mean rate of decline. Cost analysis between the two groups. Quality of life questionnaire. Patient satisfaction questionnaire and Adherence to treatment.
1 year
Positive Expiratory Pressure (PEP) - an airway clearance technique
High Frequency Chest Wall Oscillation (HFCWO) also known as the 'Vest technique' - an airway clearance technique.
Physiotherapy technique for airway clearance
Physiotherapy technique for airway clearance.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Foothills Medical Centre
Calgary, Alberta, T2N 2T9, Canada
Alberta Children's Hospital
Edmonton, Alberta, T3B 2C8, Canada
University of Alberta Hospitals
Edmonton, Alberta, T6G 2B7, Canada
BC Children's Hospital
Vancouver, British Columbia, V6H 3V4, Canada
St. Paul's Hospital
Vancouver, British Columbia, V6Z 1Y6, Canada
Children's Hospital of Winnipeg
Winnipeg, Manitoba, R3A 1S1, Canada
St. Clare's Mercy Hospital
St. John's, Newfoundland and Labrador, A1C 5B8, Canada
McIlwaine MP, Alarie N, Davidson GF, Lands LC, Ratjen F, Milner R, Owen B, Agnew JL. Long-term multicentre randomised controlled study of high frequency chest wall oscillation versus positive expiratory pressure mask in cystic fibrosis. Thorax. 2013 Aug;68(8):746-51. doi: 10.1136/thoraxjnl-2012-202915. Epub 2013 Feb 13.
Maggie McIlwaine, Physio
BC Children's Hospital, Vancouver
George Davidson, MD
BC Children's Hospital, Vancouver
Candice Bjornson, MD
Alberta Children's Hospital
Clare Smith, Physio
Alberta Children's Hospital
107 participants (actual enrollment reported by the registry).
First Submitted
January 2, 2009
First Posted
January 6, 2009
Study Start
October 2008
Date type not reportedThis date has not been verified as actual or estimated.
A Randomized-Controlled Trial of Inhaled Hypertonic Saline (7%) to Evaluate the Lung Clearance Index
Contact the study team to confirm eligibility.
Children's Hospital of Eastern Ontario
Ottawa, Ontario, K1H 8L1, Canada
Ottawa General Hospital
Ottawa, Ontario, K1H 8L6, Canada
The Hospital for Sick Children, Toronto
Toronto, Ontario, Canada
Montreal Children's Hospital
Montreal, Quebec, H3H 1P3, Canada
CHU Ste-Justine
Montreal, Quebec, H3T 1C5, Canada
Centre Mere-Enfant du CHUQ
Québec, Quebec, G1V 4G2, Canada
Hans Pasterkamp, MD
The Children's Hospital of Winnipeg
Linda Kraemer, Physio
The Children's Hospital of Winnipeg
Felix Ratjen, MD
The Hospital for Sick Children, Toronto
Jennifer Agnew, Physio
The Hospital for Sick Children, Toronto
Larry Lands, MD
Montreal Children's Hospital of the MUHC
Nancy Alarie, Physio
Montreal Children's Hospital of the MUHC
Pearce Wilcox, MD
St. Paul's Hospital, Vancouver
Brigette Wilkins, Physio
St. Paul's Hospital, Vancouver
Sherri Katz, MD
Children's Hospital of Eastern Ontario, Ottawa
Linda Lapointe, Physio
Children's Hospital of Eastern Ontario
Shawn Aaron, MD
The Ottawa Hospital
Lynne Orser, Physio
The Ottawa Hospital
Harvey Rabin, MD
Foothills Medical Centre, Calgary
Julie Wilson, Physio
Foothills Medical Centre, Calgary
Mary Noseworthy, MD
Janeway Children's Health & Rebab. Centre, St. John's
Stephanie Spencer, Physio
St. Clare's Mercy Hospital, St. John's
Peter Zuberbuhler, MD
University of Alberta Hospitals, Edmonton
Suzanne Bergsten, Physio
University of Alberta Hospitals, Edmonton
Neil Brown, MD
University of Alberta Hospitals, Edmonton
Joyce Sharum, Physio
University of Alberta Hospitals, Edmonton
Jacques-Edouard Marcotte, MD
CHU Ste-Justine, Montreal
Nadia Marquis, Physio
CHU Ste-Justine, Montreal
Patrick Daigneault, MD
CHUQ, Universite Laval, Quebec
Christine Bouchard, Physio
CHUL, Universite Laval, Quebec
Primary Completion
April 2012
Actual (reported)Study Completion
July 2012
Actual (reported)Last Updated
March 17, 2014
Record last verified: 2014-03
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.
Source retrieved: