Regulation of Hepatic Insulin Extraction

NCT00811044 | Withdrawn

• 2 other identifiers: 00-05895R01DK031842-26
• Study Type: observational
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

• This study is in the area of Type 2 diabetes and genetics
• Healthy Volunteers and those with mild type 2 diabetes may be eligible to participate
• This study is searching for genes that may affect the body's processing/digestion of glucose/sugar

Conditions

Diabetes

Keywords

diabetes; genetics; oral glucose tolerance testing; family history of diabetes; gestational diabetes

Outcome Measures

Primary Outcomes (1)

• Genes affecting the development of Type 2 diabetes will be identified

  1 year

Secondary Outcomes (1)

• Any differences between genetic groups in the metabolism of glucose/sugar will be studied to the extent that the data allow

  1 year

Study Arms (3)

Entry

This group is just entering the study and will need to be genotyped.

Affected

This group has been genotyped and has the gene undergoing study at that time.

Control

This group has been genotyped and does not have the gene currently under study.

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Healthy Volunteers \& otherwise healthy diabetic volunteers (do not require insulin for glucose control).

You may qualify if:

• ages 18-65
• non-diabetic
• diabetes controlled with diet or with pills
• no family history of diabetes
• family history of type 2 diabetes
• personal history of gestational diabetes

You may not qualify if:

• \< 18 or \> 65 years of age
• medications that affect glucose (sugar) levels
• kidney disease
• liver disease
• heart/cardiovascular disease

Sponsors & Collaborators

• Washington University School of Medicine: lead
• University of Chicago: collaborator
• National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): collaborator

Biospecimen

Retention: SAMPLES WITH DNA

Samples are collected for Glucose \& various human peptide measurements and DNA. As peptide assay evolves, specimens may be re-tested.

MeSH Terms

Conditions

Diabetes Mellitus; Diabetes, Gestational

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases

Study Officials

• Kenneth S Polonsky, MD

  Washington University School of Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 17, 2008
• First Posted: December 18, 2008
• Study Start: October 1, 2000
• Primary Completion: June 1, 2015
• Study Completion: June 1, 2015
• Last Updated: June 27, 2018

Record last verified: 2018-06