Role of Chest Ultrasound in Diagnosing and Follow-up of Pneumonia

NCT00808457 | Completed

• 3 other identifiers: 2055-06/07PD Dr. med. Angelika ReißigPhone: 00493641/ 9-32 41 28
• Study Type: observational
• Target: 397
• Locations: 1 country
• Sites: 1

Brief Summary

The study of a large number of patients (at least 200 patients) from several European centres aims to investigate the value of chest ultrasound in diagnosing and checking the course of pneumonia as compared to a chest X-ray film in two planes and - in case of a controversial X-ray finding- as compared to low-dose CT. An X-ray finding is regarded controversial, if infiltrates cannot be reliably excluded or not reliably represented and if a definite diagnosis is, thus, not possible. A low-dose CT is indicated even in case of a positive chest ultrasound and negative X-ray finding. Sonographic recording and characterization of pneumonic infiltrates is performed both at the time of diagnosing and in the further course under therapy.

Conditions

Pneumonia

Keywords

chest ultrasound; pneumonia; X-ray; CT; Sensitivity and specificity of chest ultrasound in diagnosing pneumonia

Outcome Measures

Primary Outcomes (1)

• sensitivity of chest ultrasound in diagnosing pneumonia

  baseline diagnostic

Secondary Outcomes (1)

• Specificity

  baseline diagnostic

Study Arms (1)

patients with suspected pneumonia

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with clinically suspected community-acquired pneumonia.

You may qualify if:

• Patients with clinically suspected CAP who received no antibiotic treatment yet
• Patients in whom a chest X-ray in 2 planes was already performed, can be included in the study, if chest ultrasound is performed within 24 hours after X-ray and if the X-ray finding is neither available to nor known to the examiner doing the ultrasound examination.
• Age \> 18 years
• Patient's declaration of consent is available.

You may not qualify if:

• Patients with HAP
• Age \<18 years
• Patients in whom the time difference between chest ultrasound and chest X-ray in 2 planes is more than 24 hours
• Patients whose X-ray findings are with the examiner doing the ultrasound or are known to him
• Pregnancy and lactation
• Missing declaration of consent by the patient.

Sponsors & Collaborators

• University of Jena: lead

Study Sites (1)

Pneumology, Friedrich-Schiller University Jena

Jena, Thuringia, 07740, Germany

Location

Related Publications (4)

• Reissig A, Kroegel C. Sonographic diagnosis and follow-up of pneumonia: a prospective study. Respiration. 2007;74(5):537-47. doi: 10.1159/000100427. Epub 2007 Feb 27.

  PMID: 17337882 BACKGROUND

• Copetti R, Cattarossi L. Ultrasound diagnosis of pneumonia in children. Radiol Med. 2008 Mar;113(2):190-8. doi: 10.1007/s11547-008-0247-8. Epub 2008 Apr 2. English, Italian.

  PMID: 18386121 BACKGROUND

• Reissig A, Mempel C, Schumacher U, Copetti R, Gross F, Aliberti S. Microbiological diagnosis and antibiotic therapy in patients with community-acquired pneumonia and acute COPD exacerbation in daily clinical practice: comparison to current guidelines. Lung. 2013 Jun;191(3):239-46. doi: 10.1007/s00408-013-9460-x. Epub 2013 Apr 6.

  PMID: 23564195 DERIVED

• Reissig A, Copetti R, Mathis G, Mempel C, Schuler A, Zechner P, Aliberti S, Neumann R, Kroegel C, Hoyer H. Lung ultrasound in the diagnosis and follow-up of community-acquired pneumonia: a prospective, multicenter, diagnostic accuracy study. Chest. 2012 Oct;142(4):965-972. doi: 10.1378/chest.12-0364.

  PMID: 22700780 DERIVED

MeSH Terms

Conditions

Pneumonia; Hypersensitivity

Condition Hierarchy (Ancestors)

Respiratory Tract Infections; Infections; Lung Diseases; Respiratory Tract Diseases; Immune System Diseases

Study Design

• Study Type: observational
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: December 12, 2008
• First Posted: December 15, 2008
• Study Start: September 1, 2007
• Primary Completion: February 1, 2011
• Study Completion: February 1, 2011
• Last Updated: August 15, 2011

Record last verified: 2011-08

Locations

DE (1)