Correlation of Optic Disk Morphology and Ocular Perfusion Parameters in Patients With Primary Open Angle Glaucoma

NCT00803504 | Completed DMC

• 1 other identifier: OPHT-120905
• Study Type: observational
• Target: 103
• Locations: 1 country
• Sites: 1

Brief Summary

Glaucoma is one of the most common causes of blindness in the industrialized nations. For a long time glaucoma has been defined as a disease in which high intraocular pressure (IOP) leads to irreversible optic disc damage and subsequent visual field loss. However, recent investigations show that IOP is not the only factor that is involved in the glaucomatous process leading to retinal ganglion cell death. The role of vascular factors in the pathogenesis of glaucoma has recently received much attention based on animal experiments and epidemiological studies. It is, however, assumed that vascular factors do not contribute to same degree in all glaucoma patients. Generally, it is believed that a vascular component is more important in normal tension glaucoma patients and patients with underlying cardiovascular disease. Little is, however, known about a potential association between optic nerve head morphology and ocular perfusion in POAG patients. The current study seeks to gain insight into this association by assessing ocular blood flow parameters with a number of noninvasive technologies.

Conditions

Primary Open Angle Glaucoma

Keywords

optic disc morphology; ocular blood flow; retina; ocular physiology

Outcome Measures

Primary Outcomes (6)

• Optic nerve head blood flow (scanning laser Doppler flowmetry, laser Doppler flowmetry)

• Retinal blood flow (scanning laser Doppler flowmetry, laser Doppler velocimetry + retinal vessel analyzer)

• Choroidal blood flow (laser Doppler flowmetry, laser interferometry, pneumotonometry)

• Optic nerve head morphology parameters

• Fundus photography: evaluation based on Jonas et al. 2003 J Glaucoma 12:260-265,

• Heidelberg Retina Tomograph: evaluation based on Iester et al. 2001 Am J Ophthalmol 132: 57-62,

Interventions

ocular blood flow measurement PROCEDURE

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Men and women over 18 years
• Unilateral or bilateral primary open angle glaucoma
• At least 3 reliable visual field tests showing CPSD \>= 2.0 in the eye that will be studied

You may not qualify if:

• History of acute angle closure
• Closed or barely open anterior chamber angle
• Standard deviation of visual field testing \> 10
• Intraocular surgery or argon laser trabeculoplasty within the last six months
• Ocular inflammation or infection within the last three months
• Topical or systemically/oral therapy with steroids

Sponsors & Collaborators

• Medical University of Vienna: lead

Study Sites (1)

Deparmtent of Clinical Pharmacology

Vienna, 1090, Austria

Location

MeSH Terms

Conditions

Glaucoma, Open-Angle

Condition Hierarchy (Ancestors)

Glaucoma; Ocular Hypertension; Eye Diseases

Study Officials

• Gerhard Garhöfer, MD

  Department of Clinical Pharmacology, Medical University of Vienna

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: December 3, 2008
• First Posted: December 5, 2008
• Study Start: November 1, 2006
• Study Completion: August 1, 2007
• Last Updated: December 5, 2008

Record last verified: 2008-12

Locations

AU (1)