Olfactory Dysfunction of Rhinosinusitis
ODOR
1 other identifier
observational
23
1 country
1
Brief Summary
The purpose of this research is to improve understanding of the molecular and functional properties of the human olfactory system. The specific aims are:
- to determine the location of AC3 and Golf proteins in the human olfactory epithelium from freshly harvested nasal/sinus tissue of surgical patients
- to perform objective functional studies on fresh human nasal/sinus tissue using an electro-olfactogram (EOG) whic measures the electrical activity of olfactory sensory neurons in fresh biopsied tissue in response to odor or pheromone stimulation. An organotypic culture system for human tissue has been established to optimize the electrical signal acquisition.
- to correlate the AC3 and Golf expression profiles with pre-operative testing of human olfactory function
- to correlate the EOG findings with pre-operative testing of human olfactory function.
- to systematically evaluate the role of individual intranasal agents on olfaction to further optimize the electrical signal acquisition from olfactory tissue.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Nov 2008
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
November 1, 2008
CompletedFirst Submitted
Initial submission to the registry
November 21, 2008
CompletedFirst Posted
Study publicly available on registry
November 24, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2010
CompletedStudy Completion
Last participant's last visit for all outcomes
September 1, 2010
CompletedJune 29, 2012
June 1, 2012
1.8 years
November 21, 2008
June 27, 2012
Conditions
Keywords
Study Arms (1)
endoscopic sinus procedure candidates
Eligibility Criteria
surgical patients from the UW Otolaryngology - Head and Neck surgery clinic
You may qualify if:
- over 18 yrs. of age, scheduled for: a.) endoscopic sinus surgery for chronic sinusitis, b.) endoscopic transnasal approach to the pituitary for pituitary tumor removal, c.) endoscopic inferior turbinectomy for nasal congestion d.)endoscopic repair of cerebrospinal fluid leaks
You may not qualify if:
- unable to give informed consent or complete questionnaires due to language, cognitive impairment or sever medical conditions.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Greg Davislead
Study Sites (1)
University of Washington Medical Center
Seattle, Washington, 98195, United States
Related Publications (1)
Lim JH, Davis GE, Rue TC, Storm DR. Human sinonasal explant system for testing cytotoxicity of intranasal agents. Int Forum Allergy Rhinol. 2012 Jan-Feb;2(1):63-8. doi: 10.1002/alr.20110. Epub 2011 Dec 13.
PMID: 22170775RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Greg E Davis, MD, MPH
University of Washington
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Assistant Professor
Study Record Dates
First Submitted
November 21, 2008
First Posted
November 24, 2008
Study Start
November 1, 2008
Primary Completion
September 1, 2010
Study Completion
September 1, 2010
Last Updated
June 29, 2012
Record last verified: 2012-06