Effect of Exercise on the Disease Activity of Rheumatoid Arthritis

NCT00792675 | Completed

• 1 other identifier: 0267-02-FB
• Study Type: interventional
• Target: 55
• Locations: 1 country
• Sites: 1

Brief Summary

This study will evaluate the effect of exercise on the number of swollen and tender joints associated with rheumatoid arthritis after a 12 week exercise program of treadmill walking and weightlifting.

Conditions

Rheumatoid Arthritis

Keywords

exercise; disease activity; inflammation; resistance training; rehabilitation

Outcome Measures

Primary Outcomes (2)

• Swollen Joint Count

  12 Weeks

• Tender Joint Count

  12 Weeks

Secondary Outcomes (8)

• Pain (visual Analog Scale)

  12 Weeks

• Modified-Health Assessment Questionnaire

  12 Weeks

• Estimated Aerobic Capacity (VO2max)

  12 weeks

• SF-36

  12 Weeks

• Patient Global Assessment

  12 Weeks

Study Arms (1)

Exercise

EXPERIMENTAL

Exercise consists of 30 minutes of treadmill exercise at approximately 85% of heart rate max and 2 sets of 6 resistance weight lifting exercises resulting in volitional fatigue at 12 to 15 repetitions.

Other: Aerobic and resistance exercise training

Interventions

Aerobic and resistance exercise training OTHER

Exercise was performed 3 times per week. It consisted of 30 minutes of treadmill exercise at approximately 85% of heartrate max and 2 sets of 6 resistance weight lifting exercises resulting in volitional fatigue at 12 to 15 repetitions.

Exercise

Eligibility Criteria

• Age: 19 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• a diagnosis of RA according to the ACR 1989 Criteria at least 6 months prior to enrollment in the study, but not longer than 12 years
• age 19 to 65 years old
• stable regimen of medication for 2 months with less than 10 mg/day of oral corticosteroids
• currently exercise \< 2x/week for less than 30 minutes at less than 60% of his/her age predicted maximum heart rate
• Subjects must pass the Physical Activity Readiness Scale Questionnaire (PAR-Q)

You may not qualify if:

• other serious health problems
• intra-articular injection within 6 weeks
• total joint replacement of the large joints
• use of beta-blockers
• inability to complete the submaximal exercise test

Sponsors & Collaborators

• University of Nebraska: lead
• Arthritis Foundation: collaborator
• Nebraska Chapter Arthritis Foundation: collaborator

Study Sites (1)

Physical Activity Lab, University of Nebraska Omaha

Omaha, Nebraska, 69189-4420, United States

Location

MeSH Terms

Conditions

Arthritis, Rheumatoid; Motor Activity; Inflammation

Condition Hierarchy (Ancestors)

Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Connective Tissue Diseases; Skin and Connective Tissue Diseases; Autoimmune Diseases; Immune System Diseases; Behavior; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Laura D Bilek, PhD, PT

  University of Nebraska

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 17, 2008
• First Posted: November 18, 2008
• Study Start: January 1, 2003
• Primary Completion: April 1, 2006
• Study Completion: November 1, 2006
• Last Updated: August 30, 2023

Record last verified: 2023-08

Locations

US (1)