Mechanisms of Fronto-Subcortical Dysfunction: Comparing PD and OCD
Characterizing Mechanisms of Fronto-Subcortical Dysfunction: A Comparison Between Parkinson's Disease and Obsessive-Compulsive Disorder
1 other identifier
observational
100
0 countries
N/A
Brief Summary
The purpose of this study is to characterize and compare irregularities in dopaminergic function in fronto-subcortical circuits, between Parkinson's Disease patients (ON and OFF medication) and patients with obsessive-compulsive disorder, by examining performance on cognitive tasks involving cognitive flexibility, decision-making, and attentional bias.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Dec 2008
Typical duration for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 12, 2008
CompletedFirst Posted
Study publicly available on registry
November 13, 2008
CompletedStudy Start
First participant enrolled
December 1, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2011
CompletedNovember 13, 2008
November 1, 2008
3 years
November 12, 2008
November 12, 2008
Conditions
Study Arms (4)
Parkinson's Disease
Patients with idiopathic Parkinson's disease
Obsessive-compulsive disorder
Individuals with a diagnosis of obsessive-compulsive disorder
OCD controls
Healthy controls, matched in age and number to obsessive-compulsive group
PD controls
Healthy controls, matched in age and number to Parkinson's disease group
Eligibility Criteria
private and hospital-based clinics, healthy volunteers
You may qualify if:
- idiopathic PD or
- OCD
- for control group - age-matched to study groups
You may not qualify if:
- psychotic symptoms (past or present)
- head injury with loss of consciousness
- other neurological conditions (excepting PD in PD group)
- for OCD group - use of dopaminergic medications
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Sheba Medical Centerlead
- University of Haifacollaborator
- Israel Science Foundationcollaborator
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER GOV
Study Record Dates
First Submitted
November 12, 2008
First Posted
November 13, 2008
Study Start
December 1, 2008
Primary Completion
December 1, 2011
Study Completion
December 1, 2011
Last Updated
November 13, 2008
Record last verified: 2008-11