NCT00789347

Brief Summary

The purpose of this study is to determine whether patients with neuropathic pain has abnormal excitability in somatosensory cortex and abnormal sensory-motor connections.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
80

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Oct 2008

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 1, 2008

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

November 10, 2008

Completed
1 day until next milestone

First Posted

Study publicly available on registry

November 11, 2008

Completed
2.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2011

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2011

Completed
Last Updated

April 2, 2010

Status Verified

March 1, 2010

Enrollment Period

3 years

First QC Date

November 10, 2008

Last Update Submit

April 1, 2010

Conditions

Neuropathic PainCortical Excitability

Keywords

Neuropathic painCortical excitabilityTranscranial magnetic stimulationContact Heat evoked potentialperipheral nerve stimulationneurotrophic factors

Outcome Measures

Primary Outcomes (1)

  • Abnormal cortical excitability in motor-sensory cross-talk

    non-applicable

Secondary Outcomes (1)

  • Genetic variability of neurotrophic factors between groups

    non-applicable

Study Arms (3)

1

Healthy volunteers

2

Patient with neuropathic pain

3

patients without neuropathic pain

Eligibility Criteria

Age20 Years - 65 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Primary care clinic healthy volunteer

You may qualify if:

  • Healthy volunteers
  • patients with pain resulted from dysfunction of peripheral or central nervous system
  • the disorders of peripheral nerves are diagnosed by nerve conduction study, quantitative sensory test, quantification of skin innervation or contact heat evoked potentials
  • lesion of central nervous system should be confirmed by neuroimage.

You may not qualify if:

  • previous history of epilepsy, seizure disorders or major head injury
  • previous brain surgery or intracranial metalic implant
  • implanted devices as cardiac pacemaker
  • pregnant subjects
  • patient with severe cardiac or pulmonary disease who potentially cannot tolerate stress

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

National Taiwan University Hospital

Taipei, 100, Taiwan

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Genomic polymorphism of neurotrophic factors.

MeSH Terms

Conditions

Neuralgia

Condition Hierarchy (Ancestors)

Peripheral Nervous System DiseasesNeuromuscular DiseasesNervous System DiseasesPainNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Officials

  • Ming-Kai Pan, M.D.

    National Taiwan University Hospital, Department of Neurology

    STUDY DIRECTOR

  • Chi-Chao Chao, M.D.

    National Taiwan University Hospital, Department of Neurology

    STUDY DIRECTOR

  • Sung-Tsang Hsieh, M.D. PhD

    National Taiwan University Hospital, Department of Neurology

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Ming-Kai Pan, M.D.

CONTACT

886-2-23123456emorypan@gmail.com

Ch-Chao Chao, M.D.

CONTACT

886-2-23123456ccchao@ntu.edu.tw

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER

Study Record Dates

First Submitted

November 10, 2008

First Posted

November 11, 2008

Study Start

October 1, 2008

Primary Completion

October 1, 2011

Study Completion

October 1, 2011

Last Updated

April 2, 2010

Record last verified: 2010-03

Locations

TW(1)