SSD vs Collagenase in Pediatric Burn Patients
A Prospective Comparison of Silver Sulfadiazine Cream and Collagenase Ointment for the Treatment of Burns in Children
1 other identifier
observational
100
1 country
1
Brief Summary
The objective of this study is to evaluate the outcomes of children with burn injury with regard to the utilization of Silver sulfadiazine (SSD) cream and Collagenase ointment. The primary outcome variable will be need for skin grafting. The specific aim of the study is to prospectively collect data to determine if SSD is superior to Collagenase with regard to avoiding the need for skin grafting.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Jan 2008
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2008
CompletedFirst Submitted
Initial submission to the registry
November 6, 2008
CompletedFirst Posted
Study publicly available on registry
November 7, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
January 1, 2012
CompletedJanuary 8, 2021
January 1, 2021
4 years
November 6, 2008
January 7, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Need for skin grafting
10 days
Secondary Outcomes (1)
Development of burn contractures
1 year
Study Arms (2)
Silver Sulfadiazide (SSD)
Patients that receive SSD as the topical debriding agent
Collagenase
Patients that receive collagenase as the debriding agent
Eligibility Criteria
Children between the ages of 2 months and 18 years of age that have at least second degree burns that involve less than 25% of their total body surface area.
You may qualify if:
- Partial thickness burn
- Less than 25% total body surface area burn
- Less than 18 years of age
- Greater than 2 months of age
You may not qualify if:
- Greater than 25% total body surface burn
- years of age or older
- Younger than 2 months of age
- Allergy to sulfa
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Children's Mercy Hospital and Clinics
Kansas City, Missouri, 64108, United States
Related Publications (3)
Hansbrough JF, Achauer B, Dawson J, Himel H, Luterman A, Slater H, Levenson S, Salzberg CA, Hansbrough WB, Dore C. Wound healing in partial-thickness burn wounds treated with collagenase ointment versus silver sulfadiazine cream. J Burn Care Rehabil. 1995 May-Jun;16(3 Pt 1):241-7. doi: 10.1097/00004630-199505000-00004.
PMID: 7673302BACKGROUNDOzcan C, Ergun O, Celik A, Corduk N, Ozok G. Enzymatic debridement of burn wound with collagenase in children with partial-thickness burns. Burns. 2002 Dec;28(8):791-4. doi: 10.1016/s0305-4179(02)00191-2.
PMID: 12464480BACKGROUNDAtiyeh BS, Costagliola M, Hayek SN, Dibo SA. Effect of silver on burn wound infection control and healing: review of the literature. Burns. 2007 Mar;33(2):139-48. doi: 10.1016/j.burns.2006.06.010. Epub 2006 Nov 29.
PMID: 17137719BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Daniel J Ostlie, MD
Children's Mercy Hospital and Clinics
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 6, 2008
First Posted
November 7, 2008
Study Start
January 1, 2008
Primary Completion
January 1, 2012
Study Completion
January 1, 2012
Last Updated
January 8, 2021
Record last verified: 2021-01