A Study of IMC-A12 in Participants With Tumors Who No Longer Respond to Treatment or For Whom No Treatment is Available

NCT00785538 | Completed Phase 1 Results

• 3 other identifiers: 13932CP13-0501I5A-IE-JAEH
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 3

Brief Summary

The purpose of this study is to determine if IMC-A12 is safe for participants, and also to determine the best dose of IMC-A12 to give to participants.

Conditions

Advanced Solid Tumors

Keywords

Tumors; Antibodies, Monoclonal

Outcome Measures

Primary Outcomes (2)

• Number of Participants With Adverse Events (AEs) or Deaths

  Data presented are the number of participants who experienced serious adverse events (SAEs), other non-serious AEs and deaths during the study including the 30-day follow-up. A summary of SAEs and other non-serious AEs, regardless of causality, is located in the Reported Adverse Event module.

  Enrollment to study completion up to 215 weeks

• Maximum Tolerated Dose (MTD)

  The MTD was defined as the dose preceding the dose level at which 2 participants experienced a dose-limiting toxicity (DLT). A DLT was defined as any Grade 3 or 4 hematologic or nonhematologic toxicity based on Common Terminology Criteria for AE (CTCAE), excluding alopecia, which was considered by the investigator to be definitely, probably, or possibly related to IMC-A12.

  6 weeks

Secondary Outcomes (8)

• Maximum Concentration (Cmax) of IMC-A12 Following Multiple Doses

  Predose, 0.5, 1, 2, 4, 8, 24, 48, 96, 168, 264 and 336 hours after the infusion of Cycle 1

• Observed Serum Concentration of IMC-A12 at 168 Hour Post End of Infusion Following Multiple Doses

  Predose, 0.5, 1, 2, 4, 8, 24, 48, 96, 168, 264 and 336 hours after the infusion of Cycle 1

• Area Under the Serum Concentration Versus Time Curve of IMC-A12 During One Dosing Interval (AUCτ) Following Multiple Doses

  Predose, 0.5, 1, 2, 4, 8, 24, 48, 96, 168, 264 and 336 hours after the infusion of Cycle 1

• Half-Life (t1/2) of IMC-A12 Following Multiple Doses

  Predose, 0.5, 1, 2, 4, 8, 24, 48, 96, 168, 264 and 336 hours after the infusion of Cycle 1

• Clearance Rate of IMC-A12 at Steady State (CLss) Following Multiple Doses

  Predose, 0.5, 1, 2, 4, 8, 24, 48, 96, 168, 264 and 336 hours after the infusion of Cycle 1

Study Arms (1)

IMC-A12

EXPERIMENTAL

All participants will receive intravenous (I.V.) infusions of IMC-A12, with the dose depending on which cohort they are enrolled into. A minimum of three participants will be enrolled in each cohort. When all participants complete a cohort, dose escalation to the next cohort will occur.

Biological: IMC-A12

Interventions

IMC-A12 BIOLOGICAL

Cohort 1 3 milligrams/kilogram (mg/kg), I.V. once a week, for 4 weeks, followed by a 2-week observation period.

Also known as: Cixutumumab, LY3012217

IMC-A12

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Histopathologically-documented, measurable, advanced primary or recurrent solid tumors that no longer respond to standard therapy or for which no standard therapy is available.
• Eastern Cooperative Oncology Group (ECOG) performance status score of ≤2 at study entry
• Able to provide written informed consent
• Life expectancy of \>3 months
• Adequate hematologic functions, as defined by: absolute neutrophil count (ANC) ≥1500/cubic millimeter (mm³), hemoglobin level ≥10 grams/deciliter (gm/dL), platelet count ≥100,000/mm³
• Adequate hepatic function, as defined by: total bilirubin level ≤1.5 x the upper limit of normal (ULN), aspartate transaminase (AST) and alanine transaminase (ALT) levels ≤2.5 x the ULN or ≤5 x the ULN if known liver metastases
• Adequate renal function, as defined by a serum creatinine level ≤1.5 x the ULN
• Ejection fraction within the normal institutional limits
• Use of effective contraception per institutional standard, if procreative potential exists
• At least 28 days must have elapsed from major surgery, prior chemotherapy, prior treatment with an investigational agent or device, prior radiation therapy (palliative radiation therapy is allowed), an open biopsy, or a significant traumatic injury to allow for adequate recovery. Ongoing side effects due to these agents must be ≤Grade 2 prior to entering the study.
• At least 6 weeks must have elapsed from nitrosoureas, mitomycin C, or monoclonal antibody \[not targeting the insulin-like growth factor receptor (IGFR)\] therapy to allow for adequate recovery. Ongoing side effects due to these agents must be ≤Grade 2 prior to entering the study.
• Accessible for treatment and follow-up. Participants enrolled in this trial must be treated at the participating center.

You may not qualify if:

• Any concurrent malignancy other than non-melanomatous skin cancer or carcinoma in situ of the cervix. Participants with a previous malignancy but without evidence of disease for ≥3 years will be allowed to enter the trial.
• Uncontrolled intercurrent illness including, but not limited to: ongoing or active infection requiring parenteral antibiotics, symptomatic congestive heart failure, unstable angina pectoris, angioplasty, stenting or myocardial infarction within 6 months, uncontrolled hypertension, clinically significant cardiac arrhythmia, psychiatric illness/social situations that would compromise participant safety or limit compliance with study requirements, participants with symptomatic brain metastases
• Serious or nonhealing active wound, ulcer or bone fracture
• Know human immunodeficiency virus (HIV)-positive
• History of hemorrhagic or thrombotic disorder within 9 months
• Proteinuria ≥1+ by routine urinalysis (participants with a protein value of ≤500 milligrams (mg) confirmed by a 24-hour urine collection are eligible)
• Pregnant \[confirmed by serum beta human chorionic gonadotropin (βHCG)\] or breast feeding
• History of prior treatment with other agents specifically targeting IGFRs
• Known diabetes
• Inability or unwillingness to interrupt steroidal or hormonal therapy for the duration of treatment with IMC-A12
• Positive anti-IMC-A12 antibody response
• History of allergic reactions to monoclonal antibodies or other therapeutic proteins
• Employees of the investigator or study center with direct involvement in this study or other studies under the direction of the investigator or study center, as well as family members of the employees.

Sponsors & Collaborators

• Eli Lilly and Company: lead

Study Sites (3)

ImClone Investigational Site

Scottsdale, Arizona, 85258, United States

Location

ImClone Investigational Site

Detroit, Michigan, 48201, United States

Location

ImClone Investigational Site

Seattle, Washington, 98109, United States

Location

Related Publications (1)

• Higano CS, Berlin J, Gordon M, LoRusso P, Tang S, Dontabhaktuni A, Schwartz JD, Cosaert J, Mehnert JM. Safety, tolerability, and pharmacokinetics of single and multiple doses of intravenous cixutumumab (IMC-A12), an inhibitor of the insulin-like growth factor-I receptor, administered weekly or every 2 weeks in patients with advanced solid tumors. Invest New Drugs. 2015 Apr;33(2):450-62. doi: 10.1007/s10637-015-0217-7. Epub 2015 Mar 7.

  PMID: 25749986 DERIVED

MeSH Terms

Conditions

Neoplasms

Interventions

cixutumumab

Results Point of Contact

• Title: Chief Medical Officer
• Organization: Eli Lilly and Company

800-545-5979

Study Officials

• Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)

  Eli Lilly and Company

  STUDY DIRECTOR

Publication Agreements

• PI is Sponsor Employee: No
• Restriction Type: OTHER
• Restrictive Agreement: Yes

Study Design

• Study Type: interventional
• Phase: phase 1
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SEQUENTIAL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 4, 2008
• First Posted: November 5, 2008
• Study Start: October 1, 2005
• Primary Completion: January 1, 2011
• Study Completion: January 1, 2011
• Last Updated: January 8, 2019
• Results First Posted: October 22, 2018

Record last verified: 2018-12

Locations

US (3)