NCT00783731

Brief Summary

Midazolam has been used in rapid sequence intubation for a long time, and the recommended dose is 0.1mg/kg. In some studies, however, the reduced dose has been used with the concern of hemodynamic instability. We would like to investigate that the low dose midazolam could be used rather than the standard recommended dose, and also compare it to the etomidate, recently used sedatives, with respect to the side effects and the easy performance of intubation.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Oct 2008

Typical duration for not_applicable

Geographic Reach
1 country

2 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 1, 2008

Completed
29 days until next milestone

First Submitted

Initial submission to the registry

October 30, 2008

Completed
4 days until next milestone

First Posted

Study publicly available on registry

November 3, 2008

Completed
1.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2010

Completed
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2011

Completed
Last Updated

July 26, 2011

Status Verified

July 1, 2011

Enrollment Period

2 years

First QC Date

October 30, 2008

Last Update Submit

July 25, 2011

Conditions

Intubation

Keywords

intubation

Study Arms (1)

Low dose midazolam

EXPERIMENTAL
Drug: Low dose midazolam

Interventions

Low dose midazolamDRUG
Low dose midazolam

Eligibility Criteria

Age18 Years - 90 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • patients who need rapid sequence intubation in emergency room

You may not qualify if:

  • in hypotension(systolic blood pressure less than 90 mmHg
  • severe trauma patients
  • pregnant
  • allergic to midazolam, etomidate

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Seoul National University Bundang Hospital, Emergency room

Seongnam-si, Gyeonggi-do, 463-707, South Korea

Location

Boramae Medical Center

Seoul, 156-707, South Korea

Location

MeSH Terms

Interventions

Midazolam

Intervention Hierarchy (Ancestors)

BenzodiazepinesBenzazepinesHeterocyclic Compounds, 2-RingHeterocyclic Compounds, Fused-RingHeterocyclic Compounds

Study Design

Study Type
interventional
Phase
not applicable
Purpose
TREATMENT
Sponsor Type
OTHER

Study Record Dates

First Submitted

October 30, 2008

First Posted

November 3, 2008

Study Start

October 1, 2008

Primary Completion

October 1, 2010

Study Completion

January 1, 2011

Last Updated

July 26, 2011

Record last verified: 2011-07

Locations

KR(2)