Ventricular Remodeling In Patients With Aortic Stenosis Assessed Echocardiography

NCT00774657 | Withdrawn

• 1 other identifier: 2008-090
• Study Type: observational
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

This preliminary study will compare the effectiveness of two-dimensional and three-dimensional echocardiographic measurements of wall thickness and left ventricular mass in patients with Aortic Stenosis

Conditions

Aortic Stenosis

Keywords

Aortic Stenosis; Valvular heart disease; Heart disease; Cardiovascular disease; Two dimensional echocardiography; Three dimensional echocardiography

Outcome Measures

Primary Outcomes (1)

• Evaluate 2-dimensional and 3-dimensional echocardiography for LV patterns of remodeling and hypertrophy

  1 hour

Secondary Outcomes (1)

• Assess doppler diastolic filling indices for patterns of LV remodeling

  1 hour

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Lahey Clinic patients who have been referred to the echocardiography lab for clinical indications, found to have a aortic stenosis

You may qualify if:

• Subjects more than 18 yrs of age through 90 yrs of age
• Both male and female
• Patients with moderate or severe isolated Aortic Stenosis
• Patients who have been referred for both two-dimensional and three- dimensional echocardiographies.

You may not qualify if:

• Poor acoustic windows
• h/o CAD and wall motion abnormality

Sponsors & Collaborators

• Lahey Clinic: lead
• Tufts Medical Center: collaborator

Study Sites (1)

Lahey Clinic, Inc.

Burlington, Massachusetts, 01805, United States

Location

Related Publications (4)

• Faggiano P, Rusconi C, Ghizzoni G, Sabatini T. Left ventricular remodeling and function in adult aortic stenosis. Angiology. 1994 Dec;45(12):1033-8. doi: 10.1177/000331979404501206.

  PMID: 7985830 BACKGROUND

• Kupari M, Turto H, Lommi J. Left ventricular hypertrophy in aortic valve stenosis: preventive or promotive of systolic dysfunction and heart failure? Eur Heart J. 2005 Sep;26(17):1790-6. doi: 10.1093/eurheartj/ehi290. Epub 2005 Apr 28.

  PMID: 15860517 BACKGROUND

• Salcedo EE, Korzick DH, Currie PJ, Stewart WJ, Lever HM, Goormastic M. Determinants of left ventricular hypertrophy in patients with aortic stenosis. Cleve Clin J Med. 1989 Sep;56(6):590-6. doi: 10.3949/ccjm.56.6.590.

  PMID: 2530009 BACKGROUND

• Jenkins C, Bricknell K, Hanekom L, Marwick TH. Reproducibility and accuracy of echocardiographic measurements of left ventricular parameters using real-time three-dimensional echocardiography. J Am Coll Cardiol. 2004 Aug 18;44(4):878-86. doi: 10.1016/j.jacc.2004.05.050.

  PMID: 15312875 BACKGROUND

MeSH Terms

Conditions

Aortic Valve Stenosis; Heart Valve Diseases; Heart Diseases; Cardiovascular Diseases

Condition Hierarchy (Ancestors)

Aortic Valve Disease; Ventricular Outflow Obstruction

Study Officials

• Sherif B. Labib, M.D.

  Lahey Clinic, Inc.

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 16, 2008
• First Posted: October 17, 2008
• Study Start: September 1, 2008
• Primary Completion: February 1, 2012
• Study Completion: February 1, 2012
• Last Updated: February 17, 2012

Record last verified: 2012-02

Locations

US (1)