Intermittent Preventive Treatment in Infant in Mali
1 other identifier
interventional
N/A
1 country
1
Brief Summary
Studies have shown that Intermittent preventive treatment in infants (IPTi) with Sulfadoxine-pyrimethamine (SP)reduced the incidence of clinical malaria and anemia without modifying infants' serological response to EPI vaccines. Thus IPTi was seen as a potential public health tool of great benefit to the children of Africa and a logical addition to the Immunization Plus package. The objectives of this operational researcher were
- to develop an implementation model for IPTi in the health care system in Mali
- to assess its impact on the EPI vaccines and other health interventions coverage
- and on molecular makers of resistance to SP
Trial Health
Trial Health Score
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Started Oct 2006
1 active site
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Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 2006
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2007
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2007
CompletedFirst Submitted
Initial submission to the registry
October 3, 2008
CompletedFirst Posted
Study publicly available on registry
October 6, 2008
CompletedOctober 6, 2008
September 1, 2008
1.2 years
October 3, 2008
October 3, 2008
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
EPI vaccines and other health interventions coverage
1 year
Molecular makers of resistance of P. falciparum to Sulfaxodine- pyrimethamine
1 year
Interventions
Eligibility Criteria
You may qualify if:
- Resident of Kolokani, Mali
- Age less than 24 months
You may not qualify if:
- Not Resident of Kolokani
- Age of 24 months or above
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Bamakolead
- UNICEFcollaborator
Study Sites (1)
Malaria Research & Training Center; Faculty of Medicine, Pharmacy and Dentistry, University of Bamako
Bamako, 0000, Mali
Related Publications (2)
Dicko A, Konare M, Traore D, Testa J, Salamon R, Doumbo O, Rogier C. The implementation of malaria intermittent preventive trialtreatment with sulphadoxine-pyrimethamine in infants reduced all-cause mortality in the district of Kolokani, Mali: results from a cluster randomized control. Malar J. 2012 Mar 16;11:73. doi: 10.1186/1475-2875-11-73.
PMID: 22423611DERIVEDDicko A, Toure SO, Traore M, Sagara I, Toure OB, Sissoko MS, Diallo AT, Rogier C, Salomon R, de Sousa A, Doumbo OK. Increase in EPI vaccines coverage after implementation of intermittent preventive treatment of malaria in infant with Sulfadoxine -pyrimethamine in the district of Kolokani, Mali: results from a cluster randomized control trial. BMC Public Health. 2011 Jul 18;11:573. doi: 10.1186/1471-2458-11-573.
PMID: 21767403DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Alassane Dicko, MD
Faculty of Medicine, Pharmacy and Dentistry; University of Bamako
- STUDY DIRECTOR
Ogobara K Doumbo, MD
Faculty of Medicine, Pharmacy and Dentistry; University of Bamako
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- HEALTH SERVICES RESEARCH
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
October 3, 2008
First Posted
October 6, 2008
Study Start
October 1, 2006
Primary Completion
December 1, 2007
Study Completion
December 1, 2007
Last Updated
October 6, 2008
Record last verified: 2008-09