Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure

NCT00762008 | Recruiting

• 2 other identifiers: 06-151-208145
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this research is to determine if two proteins in the blood are increased during acute heart failure. These two proteins are produced when the heart becomes dysfunctional and unable to contract normally. They may then be released into the blood and be detected by standard method in the research laboratory. Thus, the purpose of this study is to determine the relation between the change of these two proteins in the blood and the occurrence of acute heart failure. At this time, detection of an increase in these proteins in the blood is not known to be associated with any disease or heart failure.

Conditions

Acute Decompensated Heart Failure; Heart Failure

Keywords

biomarkers

Outcome Measures

Primary Outcomes (1)

• Hospitalization for acute heart failure, myocardial infarction, stroke or death.

  3 years

Study Arms (1)

Heart Failure

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Recruitment will take place in the University of Connecticut Health Center, both hospital inpatients and Cardiopulmonary clinic out-patients. 1. The target population will be heart failure patients of any etiology. We anticipate that 20% of all recruited subjects will be African American and 5% to be Hispanic. This represents the distribution of populations recruited in the past for heart failure studies. 2. Healthy individuals with no prior history of heart attack or heart failure will be recruited to use as controls.

You may qualify if:

• Individuals aged \>18yrs
• stable or decompensated heart failure, irrespective of LVEF
• decompensated heart failure clinical symptoms such as dyspnea, rales, edema, elevated jugular venous pressure, or ascites
• Imaging evidence of heart failure (cardiomegaly, poor contractile function or echocardiographic Doppler evidence of diastolic dysfunction or elevated right- or left-sided filling pressures)
• Healthy individuals with no prior history of heart attack or heart failure will be recruited to use as controls.

You may not qualify if:

• Subjects who are unable to give informed consent
• Subjects who had undergone cardiac or non-cardiac surgery in the 3 months before enrollment
• Pregnant subjects are not excluded

Sponsors & Collaborators

• UConn Health: lead
• CT Department of Public Health: collaborator

Study Sites (1)

University of Connecticut Health Center

Farmington, Connecticut, 06030, United States

RECRUITING

Biospecimen

Retention: SAMPLES WITHOUT DNA

serum

MeSH Terms

Conditions

Heart Failure

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Study Officials

• Bruce T. Liang, M.D.

  UConn Health

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Fahad E Shah

CONTACT

860-679-2692; fshah@uchc.edu

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Medicine; Director Pat and Jim Calhoun Cardiovascular Center

Study Record Dates

• First Submitted: September 26, 2008
• First Posted: September 30, 2008
• Study Start: December 1, 2005
• Primary Completion (Estimated): December 1, 2027
• Study Completion (Estimated): December 1, 2027
• Last Updated: August 12, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)