NCT00746564

Brief Summary

The goal of this IDE clinical study is to evaluate the quality of the cardiac signal recordings obtained by the St. Jude Medical (SJM) Confirm Implantable Cardiac Monitor (device).

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
75

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Sep 2008

Longer than P75 for not_applicable

Geographic Reach
1 country

9 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2008

Completed
1 day until next milestone

First Submitted

Initial submission to the registry

September 2, 2008

Completed
2 days until next milestone

First Posted

Study publicly available on registry

September 4, 2008

Completed
2.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 1, 2011

Completed
3.3 years until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2014

Completed
11 months until next milestone

Results Posted

Study results publicly available

April 30, 2015

Completed
Last Updated

January 30, 2019

Status Verified

January 1, 2019

Enrollment Period

2.4 years

First QC Date

September 2, 2008

Results QC Date

April 13, 2015

Last Update Submit

January 28, 2019

Conditions

Keywords

Implantable Cardiac MonitorArrhythmiasAtrial Fibrillation

Outcome Measures

Primary Outcomes (6)

  • Sensitivity for R Waves During In-Clinic Recordings at Rest

    The sensitivity was calculated for each recording and for each subject.

    6 weeks

  • Sensitivity for R Waves During In-Clinic Recordings During Treadmill Exercise

    The sensitivity for R waves during the in-clinic recordings was was calculated for each recording and for each subject.

    6 weeks

  • Sensitivity for R Waves During In-Clinic Recordings During Hand to Hand/Shoulder Maneuvers

    The sensitivity for R waves during the in-clinic recordings was was calculated for each recording and for each subject.

    6 weeks

  • Positive Predictive Value (PPV) for In-Clinic Recordings at Rest

    The positive predictive value (PPV) for the in-clinic recording was calculated for each recording and for each subject.

    6 weeks

  • Positive Predictive Value (PPV) for In-Clinic Recordings During Treadmill Stress Test

    The positive predictive value (PPV) for the in-clinic recording was calculated for each recording and for each subject.

    6 weeks

  • Positive Predictive Value (PPV) During Hand to Hand/Shoulder Maneuvers

    The positive predictive value (PPV) for the in-clinic recording was was calculated for each recording and for each subject.

    6 weeks

Other Outcomes (4)

  • Interpretability of Weekly Subject Activator Recordings

    6 weeks

  • Interpretability of Automatically Triggered/Symptom Driven Recordings

    6 weeks

  • Inappropriateness of Automatically Triggered Recordings - Phase I

    6 weeks

  • +1 more other outcomes

Study Arms (1)

Open Label

EXPERIMENTAL

SJM Confirm Device

Device: SJM Confirm

Interventions

All patients in this study will receive the SJM Confirm device.

Open Label

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Patients who have clinical syndromes or situations at increased risk of cardiac arrhythmias
  • Patients who experience transient symptoms that may suggest a cardiac arrhythmia
  • Patients who have been previously diagnosed with atrial fibrillation
  • Patients who are suspected to have Atrial Fibrillation (AF) but AF has not been documented
  • Patients who have provided written informed consent to participate in the study.

You may not qualify if:

  • Patients who are under the age of 18 years
  • Patients who have a life expectancy less than 1 year
  • Patients who are unable to comply with the follow-up schedule
  • Patients who are currently implanted with a pacemaker or defibrillator
  • Patients who the physician deems inappropriate for the study

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (9)

Alaska Heart Institute

Anchorage, Alaska, 99508, United States

Location

Arizona Arrhythmia Research

Scottsdale, Arizona, 85251, United States

Location

Arkansas Heart Hospital

Little Rock, Arkansas, 72211, United States

Location

St. Jude Hospital

Fullerton, California, 92835-2605, United States

Location

Scripps Clinic

La Jolla, California, 92037, United States

Location

Oklahoma Heart Institute at Utica

Tulsa, Oklahoma, 74104, United States

Location

Providence- St Vincent Medical Center

Portland, Oregon, 97225, United States

Location

Texas Cardiac Arrhythmia Research Foundation

Austin, Texas, 78705, United States

Location

University of Virginia

Charlottesville, Virginia, 22980, United States

Location

MeSH Terms

Conditions

TachycardiaSyncopeArrhythmias, CardiacAtrial Fibrillation

Condition Hierarchy (Ancestors)

Heart DiseasesCardiovascular DiseasesCardiac Conduction System DiseasePathologic ProcessesPathological Conditions, Signs and SymptomsUnconsciousnessConsciousness DisordersNeurobehavioral ManifestationsNeurologic ManifestationsNervous System DiseasesSigns and Symptoms

Results Point of Contact

Title
Director, Clinical Studies
Organization
St. Jude Medical

Study Officials

  • Tamara Shipman

    Abbott Medical Devices

    STUDY DIRECTOR

Publication Agreements

PI is Sponsor Employee
No
Restriction Type
LTE60
Restrictive Agreement
Yes

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
DIAGNOSTIC
Intervention Model
SINGLE GROUP
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 2, 2008

First Posted

September 4, 2008

Study Start

September 1, 2008

Primary Completion

February 1, 2011

Study Completion

June 1, 2014

Last Updated

January 30, 2019

Results First Posted

April 30, 2015

Record last verified: 2019-01

Locations