Assessment of a Specific Neurophysiological Brain Pattern in Patients Suffering From Chronic Back Pain
1 other identifier
observational
72
1 country
1
Brief Summary
The purpose of this study is whether patients suffering from chronic back pain for more than one year will show a specific neurophysiological pattern in the EEG. This pattern is referred to as Thalamo-Cortical Dysrhythmia (TCD) and consists most likely of a self sustaining loop between the Cortex and Thalamus. This pattern has been found before in patients with very severe chronic pain. Specific lesions to the Thalamus result in a reduction of this pattern and decrease in pain. With this study the investigators will assess whether this pattern can be found in back pain patients of different types. Patients will be measured by EEG for the existence of TCD and will undergo detailed pain and psychological diagnostic.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Aug 2008
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2008
CompletedFirst Submitted
Initial submission to the registry
August 29, 2008
CompletedFirst Posted
Study publicly available on registry
September 1, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2009
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2009
CompletedOctober 11, 2010
January 1, 2009
10 months
August 29, 2008
October 8, 2010
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Difference in EEG signature and pain perception between groups
25 months
Secondary Outcomes (1)
Quality of life, pain perception, neuropathic pain questionnaire, brief symptom inventory, life satisfaction
25 months
Study Arms (2)
1
Chronic Back Pain
2
Healthy Sex \& Age Matched Controls
Eligibility Criteria
chronic back pain
You may qualify if:
- Chronic back pain of at least one year duration
- Command of German language
- Age 18-70
You may not qualify if:
- Psychiatric disorders
- Immune suppression
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University Medical Center Freiburg
Freiburg im Breisgau, 79106, Germany
Related Publications (2)
Schmidt S, Gmeiner S, Schultz C, Lower M, Kuhn K, Naranjo JR, Brenneisen C, Hinterberger T. Mindfulness-based Stress Reduction (MBSR) as Treatment for Chronic Back Pain - an Observational Study with Assessment of Thalamocortical Dysrhythmia. Forsch Komplementmed. 2015;22(5):298-303. doi: 10.1159/000440687. Epub 2015 Oct 16.
PMID: 26565981DERIVEDSchmidt S, Naranjo JR, Brenneisen C, Gundlach J, Schultz C, Kaube H, Hinterberger T, Jeanmonod D. Pain ratings, psychological functioning and quantitative EEG in a controlled study of chronic back pain patients. PLoS One. 2012;7(3):e31138. doi: 10.1371/journal.pone.0031138. Epub 2012 Mar 14.
PMID: 22431961DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Stefan M Schmidt, PhD
Universtiy Medical Center Freiburg
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
August 29, 2008
First Posted
September 1, 2008
Study Start
August 1, 2008
Primary Completion
June 1, 2009
Study Completion
June 1, 2009
Last Updated
October 11, 2010
Record last verified: 2009-01