Heart Rate, Baroreflex Sensitivity and Cardiovascular Morbidity and Mortality in the Population

NCT00741728 | Active Not Recruiting DMC

• 2 other identifiers: C07-392007-A01386-47
• Study Type: observational
• Target: 10,157
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of the present Paris Prospective Study III (PPS3) is (1) to assess the determinants of the regulation of heart rate and blood pressure variations and carotid properties (under different physiologic stimulations) and (2) to evaluate the respective contribution of heart rate, blood pressure variations and carotid properties to cardiovascular morbidity and mortality including sudden death during 10 years at least in healthy considered subjects.

Conditions

Cardiovascular Disease; Community Based Study; Sudden Death; Blood Pressure

Keywords

epidemiology; risk factors; heart rate; baroreflex sensitivity; sudden death

Outcome Measures

Primary Outcomes (1)

• cardiovascular disease (CVD)

  incident coronary heart disease (CHD), stroke, sudden death, mortality

  through study completion, an average of 24 years

Secondary Outcomes (2)

• heart rate parameters and baroreflex sensitivity

  4 Years

• other CVD outcomes

  through study completion, an average of 24 years

Study Arms (1)

general population

Observational study of 10157 adult men and women from the general population who benefited from a free extensive health check up in Paris, France

Other: Spider flash ECG, high-precision carotid echo-tracking, step test

Interventions

Spider flash ECG, high-precision carotid echo-tracking, step test OTHER

cardiac rhythm recorded during health check up, vascular aging parameters and baroreflex sensitivity recorded during carotid echotracking of the right common carotid artery , step test during 2 minutes

general population

Eligibility Criteria

• Age: 50 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult men and women affiliated to the public French Health Insurance System who benefited from a free general health check up paid by the French Health Insurance System

You may qualify if:

• years, French speaking, given consent for genetic analysis,
• written consent for participating in the study

You may not qualify if:

• \<50 years and \>75 years,
• no French speaking,
• current pregnancy,
• chronic severe disease,
• disagreement for genetic analysis,
• step test considered as non possible or non advisable by medical decision.

Sponsors & Collaborators

• Institut National de la Santé Et de la Recherche Médicale, France: lead

Study Sites (1)

Investigations Pré cliniques et Preventives de Paris

Paris, 75016, France

Location

Related Publications (10)

• Jouven X, Empana JP, Schwartz PJ, Desnos M, Courbon D, Ducimetiere P. Heart-rate profile during exercise as a predictor of sudden death. N Engl J Med. 2005 May 12;352(19):1951-8. doi: 10.1056/NEJMoa043012.

  PMID: 15888695 BACKGROUND

• Jouven X, Zureik M, Desnos M, Courbon D, Ducimetiere P. Long-term outcome in asymptomatic men with exercise-induced premature ventricular depolarizations. N Engl J Med. 2000 Sep 21;343(12):826-33. doi: 10.1056/NEJM200009213431201.

  PMID: 10995861 BACKGROUND

• Briet M, Bozec E, Laurent S, Fassot C, London GM, Jacquot C, Froissart M, Houillier P, Boutouyrie P. Arterial stiffness and enlargement in mild-to-moderate chronic kidney disease. Kidney Int. 2006 Jan;69(2):350-7. doi: 10.1038/sj.ki.5000047.

  PMID: 16408126 BACKGROUND

• Kornet L, Hoeks AP, Janssen BJ, Houben AJ, De Leeuw PW, Reneman RS. Neural activity of the cardiac baroreflex decreases with age in normotensive and hypertensive subjects. J Hypertens. 2005 Apr;23(4):815-23. doi: 10.1097/01.hjh.0000163151.50825.e2.

  PMID: 15775787 BACKGROUND

• Empana JP, Sykes DH, Luc G, Juhan-Vague I, Arveiler D, Ferrieres J, Amouyel P, Bingham A, Montaye M, Ruidavets JB, Haas B, Evans A, Jouven X, Ducimetiere P; PRIME Study Group. Contributions of depressive mood and circulating inflammatory markers to coronary heart disease in healthy European men: the Prospective Epidemiological Study of Myocardial Infarction (PRIME). Circulation. 2005 May 10;111(18):2299-305. doi: 10.1161/01.CIR.0000164203.54111.AE. Epub 2005 May 2.

  PMID: 15867179 BACKGROUND

• Alanis GA, Boutouyrie P, Abouqateb M, Bruno RM, Andrieu M, Vedie B, Geromin D, Danchin N, Laurent S, Jouven X, Empana JP. Accelerated Vascular Aging as a Possible Mechanism of Troponin I Release in the Absence of Clinically Manifested Myocardial Injury. J Am Heart Assoc. 2025 Apr;14(7):e037718. doi: 10.1161/JAHA.124.037718. Epub 2025 Mar 27.

  PMID: 40145294 DERIVED

• Deraz O, Range H, Boutouyrie P, Chatzopoulou E, Asselin A, Guibout C, Van Sloten T, Bougouin W, Andrieu M, Vedie B, Thomas F, Danchin N, Jouven X, Bouchard P, Empana JP. Oral Condition and Incident Coronary Heart Disease: A Clustering Analysis. J Dent Res. 2022 May;101(5):526-533. doi: 10.1177/00220345211052507. Epub 2021 Dec 7.

  PMID: 34875909 DERIVED

• Lisan Q, Tafflet M, Charles MA, Thomas F, Boutouyrie P, Guibout C, Haba-Rubio J, Perier MC, Pannier B, Marques-Vidal P, Jouven X, Empana JP. Self-reported body silhouette trajectories across the lifespan and excessive daytime sleepiness in adulthood: a retrospective analysis. The Paris Prospective Study III. BMJ Open. 2018 Mar 27;8(3):e020851. doi: 10.1136/bmjopen-2017-020851.

  PMID: 29593025 DERIVED

• Simon M, Boutouyrie P, Narayanan K, Gaye B, Tafflet M, Thomas F, Guibout C, Perier MC, Pannier B, Jouven X, Empana JP. Sex disparities in ideal cardiovascular health. Heart. 2017 Oct;103(20):1595-1601. doi: 10.1136/heartjnl-2017-311311. Epub 2017 Jul 28.

  PMID: 28754808 DERIVED

• Empana JP, Perier MC, Singh-Manoux A, Gaye B, Thomas F, Prugger C, Plichart M, Wiernik E, Guibout C, Lemogne C, Pannier B, Boutouyrie P, Jouven X. Cross-sectional analysis of deprivation and ideal cardiovascular health in the Paris Prospective Study 3. Heart. 2016 Dec 1;102(23):1890-1897. doi: 10.1136/heartjnl-2016-309502. Epub 2016 Jun 27.

  PMID: 27354274 DERIVED

Related Links

• official website of the French National Institute for Health and Medical Research

Biospecimen

Retention: SAMPLES WITH DNA

Blood samples and DNA taken from fresh blood

MeSH Terms

Conditions

Cardiovascular Diseases; Death, Sudden

Interventions

Exercise Test

Condition Hierarchy (Ancestors)

Death; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Heart Function Tests; Diagnostic Techniques, Cardiovascular; Diagnostic Techniques and Procedures; Diagnosis; Respiratory Function Tests; Diagnostic Techniques, Respiratory System; Ergometry; Investigative Techniques

Study Officials

• Xavier Jouven, MD, PhD

  INSERM and APHP

  STUDY DIRECTOR

• Jean-Philippe Empana, MD, PhD

  Institut National de la Santé Et de la Recherche Médicale, France

  PRINCIPAL INVESTIGATOR

• Pierre Boutouyrie, MD, PhD

  INSERM and APHP

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 25, 2008
• First Posted: August 26, 2008
• Study Start: May 13, 2008
• Primary Completion (Estimated): June 1, 2032
• Study Completion (Estimated): December 1, 2032
• Last Updated: February 11, 2026

Record last verified: 2026-02

Locations

FR (1)