Study Stopped
Because very low number of patients were enrolled
Improving the Pregnancy Rate With Endometrial Sampling Before Intrauterine Insemination
1 other identifier
interventional
9
1 country
1
Brief Summary
Endometrial sampling improves the pregnancy rates in superovulation-IUI cycles
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Aug 2008
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2008
CompletedFirst Submitted
Initial submission to the registry
August 18, 2008
CompletedFirst Posted
Study publicly available on registry
August 20, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2011
CompletedApril 20, 2012
October 1, 2009
3 years
August 18, 2008
April 19, 2012
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
The rate of clinical pregnancy
24 months
Study Arms (2)
1
NO INTERVENTIONGroup 1 patients will receive standard superovulation-IUI treatment without endometrial sampling
2
ACTIVE COMPARATORGroup 2 patients will receive standard superovulation-IUI treatment with endometrial sampling performed in the preceding cycle. It will be done in the follicular phase not later than day 10 of the cycle
Interventions
Endometrial sampling performed in the preceding cycle. It will be done in the follicular phase not later than day 10 of the cycle
Eligibility Criteria
You may qualify if:
- All women undergoing superovulation with gonadotrophins and intrauterine insemination.
- All women with cervical factor, mild male factor and/or unexplained infertility.
- At least one patent Fallopian tube.
You may not qualify if:
- Bilateral tubal disease
- Severe male factor infertility
- Intrauterine pathology (submucosal fibroid, endometrial polyp, adhesions)
- Women with positive cervical culture and/or acute vaginal infection
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
McGill University Health Center
Montreal, Quebec, H3A 1A1, Canada
Related Publications (2)
Raziel A, Schachter M, Strassburger D, Bern O, Ron-El R, Friedler S. Favorable influence of local injury to the endometrium in intracytoplasmic sperm injection patients with high-order implantation failure. Fertil Steril. 2007 Jan;87(1):198-201. doi: 10.1016/j.fertnstert.2006.05.062.
PMID: 17197286BACKGROUNDBarash A, Dekel N, Fieldust S, Segal I, Schechtman E, Granot I. Local injury to the endometrium doubles the incidence of successful pregnancies in patients undergoing in vitro fertilization. Fertil Steril. 2003 Jun;79(6):1317-22. doi: 10.1016/s0015-0282(03)00345-5.
PMID: 12798877RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Togas Tulandi, MD, MHCM
McGill University Health Centre/Research Institute of the McGill University Health Centre
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Consultant Reproductive Endocrinology and Infertility
Study Record Dates
First Submitted
August 18, 2008
First Posted
August 20, 2008
Study Start
August 1, 2008
Primary Completion
August 1, 2011
Study Completion
August 1, 2011
Last Updated
April 20, 2012
Record last verified: 2009-10