NCT00506480

Brief Summary

The purpose of this study is to determine whether endometrial receptivity markers obtained by endometrial sampling are effective in prediction of in vivo human embryo implantation.

Trial Health

50
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
100

participants targeted

Target at P50-P75 for not_applicable

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

July 22, 2007

Completed
3 days until next milestone

First Posted

Study publicly available on registry

July 25, 2007

Completed
7 days until next milestone

Study Start

First participant enrolled

August 1, 2007

Completed
Last Updated

February 5, 2010

Status Verified

July 1, 2007

First QC Date

July 22, 2007

Last Update Submit

February 4, 2010

Conditions

Embryo Implantation

Keywords

Embryo ImplantationEndometriumendometrial implantationOocyte Donationin vitro fertilizationendometrial sampling

Outcome Measures

Primary Outcomes (1)

  • embryo implantation

    1 MONTH

Study Arms (2)

OD

EXPERIMENTAL

patients artificially prepared for OD will undergo a mock cycle consisting of estrogen and later by progesterone. a pipelle sample will be taken after 6 days of progesterone supplementation.

Procedure: endometrial sampling

IVF

EXPERIMENTAL

A pipelle sample will be taken on day 21 of the cycle before administration of GNRHa. Exact timing will be performed by counting 7 days from the LH surge.

Procedure: endometrial sampling

Interventions

endometrial samplingPROCEDURE

Endometrial biopsy is a procedure in which a tissue sample is obtained from the endometrium. This procedure is performed without anesthesia during pelvic examination. The cervix is cleaned with an antiseptic solution and then grasped with an instrument (tenaculum) to steady the uterus. A small, hollow plastic tube is gently passed into the uterine cavity. Gentle suction removes a sample of the lining. The tissue sample and instruments are removed, and the sample is examined by pathology, immunohistochemistry, PCR and western blotting.

IVFOD

Eligibility Criteria

Age18 Years - 51 Years
Sexfemale
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Patients scheduled for IVF or OD

You may not qualify if:

  • Cervical stenosis

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (1)

  • Achache H, Revel A. Endometrial receptivity markers, the journey to successful embryo implantation. Hum Reprod Update. 2006 Nov-Dec;12(6):731-46. doi: 10.1093/humupd/dml004. Epub 2006 Sep 18.

    PMID: 16982667BACKGROUND

Study Officials

  • Ariel Revel, MD

    Hadassah

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Ariel Revel, MD

CONTACT

97226777111arielr2@hadassah.org.il

Alex Simon, MD

CONTACT

97226777111asimon@md.huji.ac.il

Study Design

Study Type
interventional
Phase
not applicable
Masking
NONE
Purpose
DIAGNOSTIC
Intervention Model
PARALLEL
Sponsor Type
OTHER

Study Record Dates

First Submitted

July 22, 2007

First Posted

July 25, 2007

Study Start

August 1, 2007

Last Updated

February 5, 2010

Record last verified: 2007-07