Study Stopped
No recruitment
Comparison of Transfers of Fresh and Thawed Embryos in Patients With Prior Failed Embryo Transfer Cycles
1 other identifier
interventional
N/A
1 country
1
Brief Summary
This study seeks to determine if patients with a history of failed fresh embryo transfer(s) will have increased success rates with embryo cryopreservation and subsequent thawed embryo transfer when compared to fresh embryo transfer.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
Started Aug 2008
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2008
CompletedFirst Submitted
Initial submission to the registry
August 13, 2008
CompletedFirst Posted
Study publicly available on registry
August 15, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2009
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2009
CompletedApril 9, 2014
February 1, 2009
1 year
August 13, 2008
April 8, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Ongoing pregnancy with fetal heart motion
10 weeks gestation
Study Arms (2)
Control
ACTIVE COMPARATORPatients in the control group will undergo conventional IVF cycles with fresh blastocyst transfer.
Test group
EXPERIMENTALPatients in the Test group will have their embryos cryopreserved for transfer in a second cycle.
Interventions
Subjects in the Test group will have their embryos cryopreserved for transfer in a subsequent cycle.
Subjects in the Control group will receive fresh embryo transfer.
Eligibility Criteria
You may qualify if:
- Age 18 to 40 years
- Cycle day 3 FSH less than 10 IU/l
- At least 8 antral follicles
- At least one previous autologous embryo transfer cycle that did not result in ongoing pregnancy at 10 weeks.
You may not qualify if:
- Embryo biopsy
- Any prior fresh embryo transfer that resulted in live birth
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Fertility Center of Las Vegas
Las Vegas, Nevada, 89117, United States
Related Publications (2)
Shapiro BS, Daneshmand ST, Garner FC, Aguirre M, Thomas S. Large blastocyst diameter, early blastulation, and low preovulatory serum progesterone are dominant predictors of clinical pregnancy in fresh autologous cycles. Fertil Steril. 2008 Aug;90(2):302-9. doi: 10.1016/j.fertnstert.2007.06.062. Epub 2007 Oct 1.
PMID: 17905239BACKGROUNDShapiro BS, Daneshmand ST, Garner FC, Aguirre M, Ross R. Contrasting patterns in in vitro fertilization pregnancy rates among fresh autologous, fresh oocyte donor, and cryopreserved cycles with the use of day 5 or day 6 blastocysts may reflect differences in embryo-endometrium synchrony. Fertil Steril. 2008 Jan;89(1):20-6. doi: 10.1016/j.fertnstert.2006.08.092. Epub 2007 Jan 16.
PMID: 17224151BACKGROUND
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Bruce Shapiro, M.D.
Fertility Center of Las Vegas
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
Study Record Dates
First Submitted
August 13, 2008
First Posted
August 15, 2008
Study Start
August 1, 2008
Primary Completion
August 1, 2009
Study Completion
August 1, 2009
Last Updated
April 9, 2014
Record last verified: 2009-02