NCT00730678

Brief Summary

To investigate whether genetic polymorphisms in genes encoding proteins involved in the metabolism or effects of drugs or environmental agents influence the disposition or effects of these xenobiotic substrates. To investigate the nature of heritability and the genetic basis of pharmacogenetic traits by studying family members of individuals with specific genotypes.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
8,800

participants targeted

Target at P75+ for all trials

Timeline
95mo left

Started Aug 1998

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress78%
Aug 1998Mar 2034

Study Start

First participant enrolled

August 17, 1998

Completed
10 years until next milestone

First Submitted

Initial submission to the registry

August 6, 2008

Completed
2 days until next milestone

First Posted

Study publicly available on registry

August 8, 2008

Completed
25.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2033

Expected
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2034

Last Updated

April 29, 2026

Status Verified

April 1, 2026

Enrollment Period

35.3 years

First QC Date

August 6, 2008

Last Update Submit

April 23, 2026

Conditions

All MalignanciesChildren Being Treated for Catastrophic Illness

Keywords

MetabolismPharmacogenetic testing

Outcome Measures

Primary Outcomes (1)

  • To investigate whether genetic polymorphisms in genes encoding proteins involved in the metabolism or effects of drugs or environmental agents influence the disposition or effects of these xenobiotic substrates.

    28 years

Study Arms (1)

All Participants

All participants enrolled on this study will have blood drawn for genetic testing.

Eligibility Criteria

Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

All patients treated at St. Jude Children's Research Hospital are eligible to participate in this study.

You may qualify if:

  • Any patients under evaluation/treatment at St. Jude Children's Research Hospital (SJCRH)
  • Parents or family members of St. Jude patients
  • Non patient volunteers
  • All study subjects must provide informed consent for participation
  • Assent/Consent of the patient (parent) must be provided prior to attempts made by investigators to enroll a family member of a SJCRH patient

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

St. Jude Children's Research Hospital

Memphis, Tennessee, 38105, United States

RECRUITING

Related Links

Biospecimen

Retention: SAMPLES WITH DNA

DNA or RNA for genetic testing will typically be obtained simultaneously with blood that is drawn for clinical reasons.

Study Officials

  • Jun J Yang, Ph. D.

    St. Jude Children's Research Hospital

    PRINCIPAL INVESTIGATOR

  • Kristine Crews, PharmD, MSCI

    St. Jude Children's Research Hospital

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Jun J. Yang, Ph. D.

CONTACT

888-226-4343referralinfo@stjude.org

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 6, 2008

First Posted

August 8, 2008

Study Start

August 17, 1998

Primary Completion (Estimated)

December 1, 2033

Study Completion (Estimated)

March 1, 2034

Last Updated

April 29, 2026

Record last verified: 2026-04

Locations

US(1)