NCT00722254|Terminated
Study Stopped
This study was stopped due to poor enrollment numbers
Loading search results
This study was stopped due to poor enrollment numbers
Sponsor study identifier
Secondary identifiers
observational
15
1 country
2
Study Start
June 2006
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
February 2009
Actual (reported)Study Completion
February 2009
Actual (reported)To determine the prevalence of myelofibrosis in patients with primary pulmonary hypertension, and to discover if the fibrosis in these patients is primary (AMM) or secondary.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
February 2009
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
June 2006
Date type not reportedThis date has not been verified as actual or estimated.
July 23, 2008
Actual (reported)July 25, 2008
Actual (reported)February 2009
Actual (reported)February 2009
Actual (reported)Determine the prevalence of myelofibrosis in patients with primary pulmonary hypertension
After sample is obtained
Discover if the fibrosis in patients with primary pulmonary hypertension is primary (AMM) or secondary.
After sample is obtained
Clonality
After sample is obtained
Subjects diagnosed with primary pulmonary hypertension (PPH)
Subjects diagnosed with Primary or Secondary Myelofibrosis
Patients suffering from primary pulmonary hypertension or myelofibrosis (primary or secondary)
University of Utah
Salt Lake City, Utah, 84132, United States
VA Salt Lake City Health Care System
Salt Lake City, Utah, 84148, United States
Hoffman R, Prchal JT, Samuelson S, Ciurea SO, Rondelli D. Philadelphia chromosome-negative myeloproliferative disorders: biology and treatment. Biol Blood Marrow Transplant. 2007 Jan;13(1 Suppl 1):64-72. doi: 10.1016/j.bbmt.2006.11.003.
Chen GL, Liu E, Naidoo K, Popat U, Coetzer TL, Prchal JT. Idiopathic myelofibrosis without dacryocytes. Haematologica. 2006 Jun;91(6 Suppl):ECR29.
Popat U, Frost A, Liu E, Guan Y, Durette A, Reddy V, Prchal JT. High levels of circulating CD34 cells, dacrocytes, clonal hematopoiesis, and JAK2 mutation differentiate myelofibrosis with myeloid metaplasia from secondary myelofibrosis associated with pulmonary hypertension. Blood. 2006 May 1;107(9):3486-8. doi: 10.1182/blood-2005-08-3319. Epub 2006 Jan 17.
Whole Blood
Josef T Prchal, MD
University of Utah
15 participants (actual enrollment reported by the registry).
First Submitted
July 23, 2008
First Posted
July 25, 2008
Study Start
June 2006
Date type not reportedThis date has not been verified as actual or estimated.
Polycythemia Vera, Myelofibrosis and Essential Thrombocythemia: Identification of PV, MF & ET Genes
Contact the study team to confirm eligibility.
Popat U, Frost A, Liu E, May R, Bag R, Reddy V, Prchal JT. New onset of myelofibrosis in association with pulmonary arterial hypertension. Ann Intern Med. 2005 Sep 20;143(6):466-7. doi: 10.7326/0003-4819-143-6-200509200-00017. No abstract available.
Xu M, Bruno E, Chao J, Huang S, Finazzi G, Fruchtman SM, Popat U, Prchal JT, Barosi G, Hoffman R; MPD Research Consortium. Constitutive mobilization of CD34+ cells into the peripheral blood in idiopathic myelofibrosis may be due to the action of a number of proteases. Blood. 2005 Jun 1;105(11):4508-15. doi: 10.1182/blood-2004-08-3238. Epub 2005 Feb 10.
Phelan JT 2nd, Prchal JT. Clonality studies in cancer based on X chromosome inactivation phenomenon. Methods Mol Med. 2002;68:251-70. doi: 10.1385/1-59259-135-3:251. No abstract available.
Damps-Konstanska I, Konstanski Z, Jassem E. [Treatment of pulmonary hypertension]. Wiad Lek. 2007;60(11-12):545-9. Polish.
Cortelezzi A, Gritti G, Del Papa N, Pasquini MC, Calori R, Gianelli U, Cortiana M, Parati G, Onida F, Sozzi F, Vener C, Bianchi P, Deliliers GL. Pulmonary arterial hypertension in primary myelofibrosis is common and associated with an altered angiogenic status. Leukemia. 2008 Mar;22(3):646-9. doi: 10.1038/sj.leu.2404943. Epub 2007 Sep 13. No abstract available.
Halank M, Marx C, Baretton G, Muller KM, Ehninger G, Hoffken G. Severe pulmonary hypertension in chronic idiopathic myelofibrosis. Onkologie. 2004 Oct;27(5):472-4. doi: 10.1159/000080368.
Primary Completion
February 2009
Actual (reported)Study Completion
February 2009
Actual (reported)Last Updated
March 21, 2016
Record last verified: 2016-03
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.
Source retrieved: