NCT00714987

Withdrawn

The EVLW for Set the Positive End Expiratory Pressure (PEEP)...

University Hospital, Strasbourg, France Source

Compare

Other study identifiers

Sponsor study identifier

3800

Study Type

observational

Estimated enrollment

40

Locations

0 countries

Sites

N/A

Timeline

Study Start

January 2009

Date type not reported

This date has not been verified as actual or estimated.

Primary Completion

February 2009

Estimated (date passed)

This estimate has passed. The registry has not confirmed an actual date for this milestone.

Study Completion

February 2009

Estimated (date passed)

This estimate has passed. The registry has not confirmed an actual date for this milestone.

Brief Summary

ARDS is a severe pathology with high mortality and morbidity.Actual ventilatory management is clear for the set of the tidal volume and for the survey of the plateau pressure for the patients who require mechanical ventilation.
The set of the PEEP (low or high levels) remains unclear : it seems that some patients need low levels of PEEP whereas anther need high levels; but there is no validated data that can discriminate them.
We hypothesized that patients with low levels of EVLW ( measured with the Picco® system ) need low level of PEEP to ameliorate their oxygenation ( measured with the PaO2/FiO2 ratio ) whereas patients with high levels of EVLW) need high levels of PEEP.

Registry Overview

Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.

Recruitment status: withdrawn
Estimated enrollment: 40 participants
Study completion date: February 2009
Estimated (date passed)
This estimate has passed. The registry has not confirmed an actual date for this milestone.
Listed locations: 0 countries · 0 sites

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.

First Submitted
July 7, 2008
Actual (reported)
First Posted
July 14, 2008
Actual (reported)
Study Start
January 2009
Date type not reported
This date has not been verified as actual or estimated.
Primary Completion
February 2009
Estimated (date passed)
This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
February 2009
Estimated (date passed)
This estimate has passed. The registry has not confirmed an actual date for this milestone.

Last Updated: September 17, 2009
Status Verified: September 2009
Last Update Submitted: September 16, 2009

Conditions

Acute Respiratory Distress Syndrome

Keywords

ARDSMechanical ventilationPEEP with low levelPEEP with high levelEVLWPicco® systemPaO2/FiO2 ratio

Outcome Measures

Primary Outcomes (1)

Estimate the Lung Water Extra-Vascular as predictive marker of the answer (Variation of needs in oxygen) to the ventilatory strategy: the low level, and high level of pressure positive expiratory, in the SDRA
During all the period of stay of the patient Intensive care unit

Study Arms (2)

1: High level PEEP

2: Low level PEEP

Eligibility Criteria

Age18 Years+

Sexall

Healthy VolunteersNo

Age GroupsAdult (18-64), Older Adult (65+)

Sampling MethodProbability Sample

Study Population

All patients mechanically ventilated, monitored with the Picco® system, hospitalized in a medical critical care unit of an university hospital

You may qualify if:

age\>18;

Sponsors & Collaborators

University Hospital, Strasbourg, France
Otherlead

MeSH Terms

Conditions

Respiratory Distress Syndrome

Condition Hierarchy (Ancestors)

Lung DiseasesRespiratory Tract DiseasesRespiration Disorders

Study Officials

Fady KARA, MD
University Hospital, Strasbourg, France
PRINCIPAL INVESTIGATOR

Study Design

Study Type: observational
Observational Model: CASE CONTROL
Time Perspective: PROSPECTIVE
Sponsor Type: OTHER

Study Record Dates

First Submitted

July 7, 2008

First Posted

July 14, 2008

Study Start

January 2009

Date type not reported

This date has not been verified as actual or estimated.

Primary Completion

February 2009

Estimated (date passed)

NCT01677130

Standardized Application of High Frequency Oscillatory Ventilation in the Acute Respiratory Distress Syndrome (ARDS)

Completed

NCT01506401

The Oscillation for Acute Respiratory Distress Syndrome (ARDS) Treated Early (OSCILLATE) Trial

Phase 3Terminated

NCT00284102

PEEP Test and Gas Exchange in ALI/ARDS Patients

Not ApplicableCompleted

NCT01714583

The Relationship Between Positive End Expiratory Pressure and Cardiac Index in Patients With Acute Respiratory Distress Syndrome (ARDS) Managed on a Fluid Protocol

Completed

NCT05736185

Effect of Electric Impedance Tomography-Guided PEEP Titration

Not ApplicableCompleted

NCT02944279

Neutrophil Elastase and Elafin as Prognostic Biomarker for Acute Respiratory Distress Syndrome

Completed

ARDS criteria.

You may not qualify if:

severe pulmonary hypertension;
chronic right ventricular failure;
pulmonary embolism;
tricuspidian valvulopathy;
history of spontaneous pneumothorax;
severe emphysema;
bronchomalacia;
recent pulmonary surgery;
BMI\>40;
Interstitial pulmonary fibrosis;
End of life;
Chronic neuromyopathie;
Recent neurosurgery or intracranian hypertension;
Pregnancy.

Contact the study team to confirm eligibility.

This estimate has passed. The registry has not confirmed an actual date for this milestone.

Study Completion

February 2009

Estimated (date passed)

This estimate has passed. The registry has not confirmed an actual date for this milestone.

Last Updated

September 17, 2009

Record last verified: 2009-09

Source record

Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.

Source: ClinicalTrials.gov.

JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.

Registry identifier: NCT00714987
Data provider: ClinicalTrials.gov
Source updated: 2009-09-17
Normalization version: ctgov-legacy-1

Open registry record

Source retrieved: 2026-10-25 22:19:47 UTC

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Study Arms (2)

1: High level PEEP

2: Low level PEEP

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Study Design

Study Record Dates

You may not qualify if:

Source record