NCT00706329

Brief Summary

The purpose of the study is to test the use of "Deflux" injections in a minimally invasive closure of umbilical (belly button) hernias in infants between birth and five years. The study is designed to demonstrate that the use of this device can safely and effectively close an umbilical hernia.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
25

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Apr 2008

Geographic Reach
1 country

1 active site

Status
terminated

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2008

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

June 25, 2008

Completed
2 days until next milestone

First Posted

Study publicly available on registry

June 27, 2008

Completed
8 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2009

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2009

Completed
4.5 years until next milestone

Results Posted

Study results publicly available

August 28, 2013

Completed
Last Updated

November 6, 2017

Status Verified

October 1, 2017

Enrollment Period

11 months

First QC Date

June 25, 2008

Results QC Date

June 5, 2013

Last Update Submit

October 4, 2017

Conditions

Keywords

Minimally invasive surgeryUmbilical herniaInfant

Outcome Measures

Primary Outcomes (1)

  • Close Belly Button or Umbilical Hernia

    The study was terminated prematurely by the IRB. Results are not shared due to data integrity concerns. These concerns are outlined in an FDA warning letter.

    After surgery, subjects will be followed at intervals of one month and six months from date of surgery.

Study Arms (1)

Deflux

EXPERIMENTAL

Treatment with Deflux.

Device: Deflux

Interventions

DefluxDEVICE

Patients undergo surgery using Deflux to correct umbilical hernia

Deflux

Eligibility Criteria

Age1 Year - 5 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17)

You may qualify if:

  • Age 1-5 years
  • Umbilical hernia\>1cm. diameter.
  • Undergoing either a general surgical or urologic procedure under general anesthesia other than umbilical hernia repair.
  • No previous umbilical hernia repair.

You may not qualify if:

  • Over 5 years
  • No umbilical hernia
  • No other surgery required
  • Previous umbilical hernia repair

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Children's Hospital Boston and South Shore Hospital

South Weymouth, Massachusetts, 02190, United States

Location

MeSH Terms

Conditions

Hernia, Umbilical

Condition Hierarchy (Ancestors)

Infant, Newborn, DiseasesCongenital, Hereditary, and Neonatal Diseases and AbnormalitiesHernia, VentralHernia, AbdominalHerniaPathological Conditions, AnatomicalPathological Conditions, Signs and Symptoms

Limitations and Caveats

The study was terminated prematurely by the IRB due to data integrity and compliance concerns. Results are not shared due to data integrity concerns. These concerns are outlined in an FDA warning letter.

Results Point of Contact

Title
Dr. Neil Feins
Organization
Children's Hospital Boston and South Shore Hospital

Study Officials

  • Neil R. Feins, M.D.

    Children's Hospital Boston and South Shore Hospital

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
Yes
Restrictive Agreement
No

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 25, 2008

First Posted

June 27, 2008

Study Start

April 1, 2008

Primary Completion

March 1, 2009

Study Completion

March 1, 2009

Last Updated

November 6, 2017

Results First Posted

August 28, 2013

Record last verified: 2017-10

Locations