The Genetics of Cardiomyopathy and Heart Failure

NCT00703443 | Withdrawn

• 2 other identifiers: HS# 2007-5577NIH/NHLBI 5K08HL081222-02
• Study Type: observational
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to determine the genetic basis of cardiomyopathies and heart failure.

Conditions

Dilated Cardiomyopathy; Hypertrophic Cardiomyopathy; Mitochondrial Cardiomyopathy; Noncompaction Cardiomyopathy; Restrictive Cardiomyopathy

Keywords

Genetics; Dilated Cardiomyopathy; Hypertrophic Cardiomyopathy; Mitochondrial Cardiomyopathy; Noncompaction Cardiomyopathy; Restrictive Cardiomyopathy; Heart Failure

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

We are recruiting both local participants (who have been evaluated at UCI) and remote participants (who have been referred from outside UCI) with familial and simplex cases of hypertrophic, dilated, noncompaction, restrictive, and mitochondrial cardiomyopathies. As a control group, we are also recruiting patients with nuclear mutations known to increase the risk of cardiomyopathy, but who have not themselves developed cardiomyopathy.

You may qualify if:

• Individuals with a diagnosis of cardiomyopathy
• Family members of individuals with a diagnosis of cardiomyopathy
• Individuals with a nuclear mutation shown to confer risk of cardiomyopathy but who do not themselves have cardiomyopathy

You may not qualify if:

• Individuals who do not have cardiomyopathy, a relative with cardiomyopathy, or a nuclear mutation predisposing to cardiomyopathy

Sponsors & Collaborators

• University of California, Irvine: lead

Study Sites (1)

University of California, Irvine

Irvine, California, 92697, United States

Location

Related Publications (1)

• Zaragoza MV, Arbustini E, Narula J. Noncompaction of the left ventricle: primary cardiomyopathy with an elusive genetic etiology. Curr Opin Pediatr. 2007 Dec;19(6):619-27. doi: 10.1097/MOP.0b013e3282f1ecbc.

  PMID: 18025927 BACKGROUND

Biospecimen

Retention: SAMPLES WITH DNA

Whole blood, Saliva, Buccal cells

MeSH Terms

Conditions

Cardiomyopathy, Dilated; Cardiomyopathy, Hypertrophic; Cardiomyopathy, Restrictive; Heart Failure

Condition Hierarchy (Ancestors)

Cardiomegaly; Heart Diseases; Cardiovascular Diseases; Cardiomyopathies; Laminopathies; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Aortic Stenosis, Subvalvular; Aortic Valve Stenosis; Aortic Valve Disease; Heart Valve Diseases

Study Officials

• Michael V Zaragoza, M.D., Ph.D.

  University of California, Irvine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: FAMILY BASED
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 19, 2008
• First Posted: June 23, 2008
• Study Start: April 1, 2007
• Primary Completion: April 1, 2007
• Study Completion: April 1, 2007
• Last Updated: January 25, 2021

Record last verified: 2021-01

Locations

US (1)