Exercise Training and Glucose Metabolism in Aging
Aging, Angiogenesis and Metabolic Responses to Aerobic Exercise
3 other identifiers
interventional
90
1 country
1
Brief Summary
Diabetes and its associated complications affect more than 20 million Americans, and the prevalence of type 2 diabetes and impaired glucose tolerance rises dramatically with age such that 40% of Americans over age 60 are affected. In older adults, glucose metabolism may be affected by reduced skeletal muscle capillary supply, which limits insulin, glucose, and oxygen delivery to skeletal muscle. Reduced capillary supply to skeletal muscle is found in older individuals with impaired glucose tolerance and we hypothesize that this is due to reduced vascular growth factor expression, and chronic inflammation. Further, we hypothesize that reversal of a sedentary lifestyle through aerobic exercise training will increase insulin signaling and vascular growth factor expression, as well as decrease inflammation, to increase capillary supply to skeletal muscle, which contributes to improved glucose metabolism in older adults. This study will: 1) Determine the mechanisms underlying reduced skeletal muscle capillarization in older adults with impaired glucose tolerance; and 2) Determine the effect of aerobic exercise training-induced increases in skeletal muscle capillarization on glucose metabolism in older adults.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable type-2-diabetes-mellitus
Started Oct 2006
Longer than P75 for not_applicable type-2-diabetes-mellitus
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 2006
CompletedFirst Submitted
Initial submission to the registry
June 18, 2008
CompletedFirst Posted
Study publicly available on registry
June 19, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2012
CompletedResults Posted
Study results publicly available
April 6, 2015
CompletedApril 6, 2015
March 1, 2015
5.7 years
June 18, 2008
January 26, 2015
March 23, 2015
Conditions
Outcome Measures
Primary Outcomes (4)
Baseline Glucose Utilization
Insulin-stimulated glucose uptake
baseline
Glucose Utilization (Pre/Post Intervention)
Insulin-stimulated glucose uptake
baseline, 24 weeks, 26 weeks
Baseline Skeletal Muscle Capillarization
baseline
Skeletal Muscle Capillarization (Pre/Post Intervention)
baseline, 24 weeks, 26 weeks
Secondary Outcomes (5)
Baseline 2-hour Postprandial Glucose
baseline
2-hr Post-prandial Plasma Glucose Level
baseline, 24 weeks, 26 weeks
Baseline Cardiorespiratory Fitness
baseline
Cardiorespiratory Fitness
baseline, 24 weeks, 26 weeks
Body Composition (%Fat)
baseline, 24 weeks
Study Arms (2)
Arm 1
ACTIVE COMPARATOROlder adults, normal glucose tolerance
Arm 2
EXPERIMENTALOlder adults, impaired glucose tolerance
Interventions
24 weeks of aerobic exercise training: 3 times per week, 60 minutes per session, at 70% of maximal aerobic capacity
Eligibility Criteria
You may qualify if:
- Age 50-75 years
- Non-smoker \>2 years
- Body mass index = 18-35 kg/m2
You may not qualify if:
- History of CAD or cerebrovascular disease that would preclude exercise
- Implantable defibrillator
- Active cancer
- Chronic pulmonary, thyroid, renal, liver, or hematological disease
- HIV positive or prone to malnutrition
- Sickle cell anemia
- Type 1 diabetes, or currently on medication to treat type 2 diabetes
- Poorly-controlled type 2 diabetes
- Poorly-controlled hypertension
- Taking medications including: beta-blockers, oral steroids, warfarin, certain statins, hormone replacement therapy (HRT), oral contraceptives (OCP), thiazolidinediones (TZD), or chronic steroids or nonsteroidal analgesics (NSAIDS) that may not be safely discontinued temporarily for specific procedures (i.e. for 72 hours prior)
- Allergic to lidocaine or heparin
- Recent weight change (\>5kg in 3 months)
- Currently pregnant or nursing
- Physical impairment limiting exercise
- Dementia or unstable clinical depression
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- US Department of Veterans Affairslead
- University of Marylandcollaborator
- National Institutes of Health (NIH)collaborator
- National Institute on Aging (NIA)collaborator
Study Sites (1)
VA Maryland Health Care System, Baltimore
Baltimore, Maryland, 21201, United States
Related Publications (1)
Prior SJ, Goldberg AP, Ortmeyer HK, Chin ER, Chen D, Blumenthal JB, Ryan AS. Increased Skeletal Muscle Capillarization Independently Enhances Insulin Sensitivity in Older Adults After Exercise Training and Detraining. Diabetes. 2015 Oct;64(10):3386-95. doi: 10.2337/db14-1771. Epub 2015 Jun 11.
PMID: 26068543DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Results Point of Contact
- Title
- Steven J. Prior, PhD
- Organization
- Baltimore VA Medical Center
Study Officials
- PRINCIPAL INVESTIGATOR
Steven J. Prior, PhD
VA Maryland Health Care System, Baltimore
Publication Agreements
- PI is Sponsor Employee
- Yes
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- FED
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 18, 2008
First Posted
June 19, 2008
Study Start
October 1, 2006
Primary Completion
June 1, 2012
Study Completion
June 1, 2012
Last Updated
April 6, 2015
Results First Posted
April 6, 2015
Record last verified: 2015-03