The Prevalence of Gastro-oesophageal Reflux in Chronic Lung Disease

NCT00697177 | Completed

• 2 other identifiers: 106/05CTG008/05
• Study Type: observational
• Target: 75
• Locations: 1 country
• Sites: 1

Brief Summary

Gastric reflux into the oesophagus may further lung damage in respiratory disease. The proportion of adults with chronic lung disease and gastric reflux is unknown. Adults with this disease regularly complete physiotherapy but the contribution of physiotherapy to reflux is unknown. This study will measure gastric reflux in adults with chronic lung disease, using 24 hour acid monitoring. It is anticipated that approximately 50% of adults with chronic lung disease will have gastric reflux. After monitoring, the number of gastric reflux episodes will be calculated. The results will identify the extent of the gastric reflux problem in these patients and will enable appropriate medical treatment and modifications to physiotherapy, which may improve lung function and quality of life.

Conditions

Chronic Obstructive Pulmonary Disease; Bronchiectasis

Keywords

Gastro-oesophageal reflux; 24 hour oesophageal pH monitoring; Physiotherapy Airway clearance techniques; Exercise

Outcome Measures

Primary Outcomes (1)

• Prevalence of GOR

  12 months

Eligibility Criteria

• Age: 20 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adults with COPD and bronchiectasis

You may qualify if:

• Diagnosis of Chronic obstructive pulmonary disease according to GOLD classification
• Diagnosis of Bronchiectasis
• Medically stable, without hospital admission in month prior to study

You may not qualify if:

• diagnosis of asthma, cystic fibrosis, interstitial lung disease
• known hiatus hernia, oesophageal varices, obstructive sleep apnoea
• medically unstable for exercise

Sponsors & Collaborators

• Bayside Health: lead
• University of Melbourne: collaborator

Study Sites (1)

Alfred Hospital

Melbourne, Victoria, 3004, Australia

Location

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive; Bronchiectasis; Gastroesophageal Reflux; Motor Activity

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Bronchial Diseases; Esophageal Motility Disorders; Deglutition Disorders; Esophageal Diseases; Gastrointestinal Diseases; Digestive System Diseases; Behavior

Study Officials

• Annemarie L Lee, BPhys, MPhys

  University of Melbourne

  PRINCIPAL INVESTIGATOR

• Brenda M Button, DPhysio, PhD

  The Alfred

  PRINCIPAL INVESTIGATOR

• John W Wilson, MBBS, PhD

  The Alfred

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 9, 2005
• First Posted: June 13, 2008
• Study Start: July 1, 2005
• Primary Completion: June 1, 2009
• Study Completion: June 1, 2009
• Last Updated: February 15, 2013

Record last verified: 2005-09

Locations

AU (1)