Studying Patterns, Causes, and Control of Disease in Patients With Lung Cancer in the North Trent (England) Region

NCT00693836 | Unknown

• 3 other identifiers: CRC-WPH-USMS-ReSoLuCENTCDR0000589308EU-20826
• Study Type: observational
• Target: 2,000
• Locations: 1 country
• Sites: 1

Brief Summary

RATIONALE: Gathering information about genetic and environmental factors from patients with lung cancer and their partners and first-degree relatives may help doctors learn more about the disease. PURPOSE: This clinical trial is looking at the patterns, causes, and control of disease in patients with lung cancer in the North Trent (England) region.

Conditions

Lung Cancer

Keywords

stage I non-small cell lung cancer; stage II non-small cell lung cancer; stage IIIA non-small cell lung cancer; stage IIIB non-small cell lung cancer; stage IV non-small cell lung cancer; recurrent non-small cell lung cancer; extensive stage small cell lung cancer; limited stage small cell lung cancer; recurrent small cell lung cancer

Outcome Measures

Primary Outcomes (1)

• Establishment of a resource bank of high quality genomic and plasma DNA and tumor and serum samples

Secondary Outcomes (2)

• Analysis of single nucleotide polymorphisms for candidate lung cancer susceptibility genes in genomic DNA samples

• Genetic changes of lung cancer in plasma DNA samples

Interventions

genetic linkage analysis GENETIC

loss of heterozygosity analysis GENETIC

mutation analysis GENETIC

polymerase chain reaction GENETIC

polymorphism analysis GENETIC

biologic sample preservation procedure OTHER

medical chart review OTHER

questionnaire administration OTHER

evaluation of cancer risk factors PROCEDURE

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

DISEASE CHARACTERISTICS: * Patient meeting the following criteria: * Pathologically confirmed lung cancer or planning to undergo lung cancer surgery pending pathological confirmation * Evidence of active disease (i.e., not in remission) * Meets 1 of the following criteria: * 60 years of age and under * Has a first-degree relative with lung cancer who is 60 years of age and under * Has two or more first- or second-degree relatives with lung cancer at any age * Control meeting the following criteria: * Co-habiting partner of patient OR first-degree relative of patient or their partner * 18 years of age and over * Resides within the North Trent Cancer Network region PATIENT CHARACTERISTICS: * Able and willing to complete study procedures PRIOR CONCURRENT THERAPY: * Not specified

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• Cancer Research Centre at Weston Park Hospital: lead

Study Sites (1)

Cancer Research Centre at Weston Park Hospital

Sheffield, England, S1O 2SJ, United Kingdom

RECRUITING

MeSH Terms

Conditions

Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Small Cell Lung Carcinoma

Interventions

Genetic Linkage; Polymerase Chain Reaction; Amplified Fragment Length Polymorphism Analysis

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases; Carcinoma, Bronchogenic; Bronchial Neoplasms

Intervention Hierarchy (Ancestors)

Genetic Phenomena; Nucleic Acid Amplification Techniques; Genetic Techniques; Investigative Techniques; DNA Fingerprinting

Study Officials

• Penella J. Woll, MD, PhD

  Cancer Research Centre at Weston Park Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: June 6, 2008
• First Posted: June 9, 2008
• Study Start: January 1, 2006
• Primary Completion: October 1, 2010
• Last Updated: August 12, 2013

Record last verified: 2008-12

Locations

GB (1)