Knowledge and Perception of Smoking Risks/Consequences

NCT00686101 | Completed

• 2 other identifiers: HP-00042643NIDA #425
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 2

Brief Summary

This proposed 2-year questionnaire study examines views and attitudes regarding health risks of cigarette smoking, smoking patterns and motivators for cessation in smokers who suffer from schizophrenia compared to a sample of smokers without a major psychotic disorder.

Conditions

Cigarette Smoking; Schizophrenia

Keywords

Perception of risk; Smoking risks; Smoking consequences; Quitting smoking; Motivation to quit smoking; Schizophrenia

Outcome Measures

Primary Outcomes (1)

• The measure will be the differences in smoking perceptions/risk and motivation as assessed by the questionnaires between smokers with and without schizophrenia.

  For each subject, the time frame primarily evaluated will be the length of his or her use of cigarettes, primarily (but the time frame may be extended to include other evaluated factors, such as education or family/economic support).

Study Arms (2)

1

Normal control subjects (Males and females between 18-65 years, who smoke cigarettes daily, have an expired CO measurement of \> 8 ppm to confirm cigarette smoking, who are not actively trying to quit smoking at the time of the interview, and who must be free from Axis I psychotic disorder.)

2

Subjects with a DSM-IV diagnosis of schizophrenia or schizoaffective disorder (Males and females between 18-65 years, who smoke cigarettes daily, have an expired CO measurement of \> 8 ppm to confirm cigarette smoking, and who are not actively trying to quit smoking at the time of the interview.)

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patient volunteers will be recruited from the MPRC Outpatient and Inpatient Programs and through NIDA. Control subjects will be recruited by MPRC and NIDA via newspaper advertisements from the Baltimore metropolitan area. We anticipate recruiting up to 110 schizophrenia patients for a total of 100 completers and up to 110 normal controls for a total of 100 completers. All participants will be 18-65 years old, will smoke cigarettes daily, and must not be interested in reducing or quitting tobacco use. Nicotine dependence appears to be about equally represented among ethnic and racial backgrounds and gender.

You may qualify if:

• Males and females between 18-65 years
• Minimum of 5 cigarettes daily.
• Expired CO measurement of \> 8 ppm to confirm cigarette smoking
• For the schizophrenia group, must have a DSM-IV diagnosis of schizophrenia or schizoaffective disorder.

You may not qualify if:

• For the normal control group, must be free from Axis I psychotic disorder. (other psychiatric comorbidity will not be excluded)
• For all subjects, anyone actively trying to quit smoking at the time of the interview.

Sponsors & Collaborators

• University of Maryland, Baltimore: lead
• National Institute on Drug Abuse (NIDA): collaborator

Study Sites (2)

National Institute on Drug Abuse (Johns Hopkins Bayview Campus)

Baltimore, Maryland, 21224, United States

Location

Maryland Psychiatric Research Center, University of Maryland School of Medicine

Baltimore, Maryland, 21228, United States

Location

MeSH Terms

Conditions

Cigarette Smoking; Schizophrenia; Smoking Cessation

Condition Hierarchy (Ancestors)

Tobacco Smoking; Smoking; Behavior; Tobacco Use; Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders; Health Behavior

Study Officials

• Deanna L Kelly, PharmD, BCPP

  University of Maryland, College Park

  PRINCIPAL INVESTIGATOR

• Steve Heishman, MD

  National Institute on Drug Abuse (NIDA)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Deanna L. Kelly, Pharm.D., BCPP, Cheif Treatment Research Program

Study Record Dates

• First Submitted: May 27, 2008
• First Posted: May 29, 2008
• Study Start: December 1, 2007
• Primary Completion: June 1, 2009
• Study Completion: June 1, 2009
• Last Updated: November 4, 2019

Record last verified: 2019-10

Locations

US (2)