Redox State in the Course of Chronic Renal Insufficiency and Hemodialysis: Implications in Morbimortality

NCT00684034 | Completed

• 2 other identifiers: 2007-A01179-442007-38
• Study Type: interventional
• Target: 131
• Locations: 1 country
• Sites: 1

Brief Summary

The influence of hemodialysis on oxidative stress, endothelial activation, inflammation and on the redox state of lymphocytes should be clarified as well as the putative relationships between all these parameters.

Conditions

Chronic Renal Insufficiency

Keywords

Redox state in the course of chronic renal insufficiency and hemodialysis.

Outcome Measures

Primary Outcomes (1)

• This study should allow to clarify the redox state some plasma by quantification of thiols membranous on the surface of lymphocytes at the hemodialysis and insufficient renal chronic not dialysed patients.

  48 months

Secondary Outcomes (1)

• This study should allow to estimate in a forward-looking longitudinal plan the possible involvement of the parameters of the redox state and the morbidity and the cardiovascular and global mortality in 2 years in 2 studied populations.

  48 months

Study Arms (3)

1

OTHER

Volunteer healthy

Other: Sampling of blood

2

OTHER

Patient dialysis patient

Other: Sampling of blood

3

OTHER

Not dialysed chronic renal insufficient patient

Other: Sampling of blood

Interventions

Sampling of blood OTHER

A sampling of blood will be made

1

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• and 80 years old man or woman dialysing at least 3 times a week for at least 6 months and having no residual renal function
• Rate of haemoglobin \> 11 g / dl
• Clinically stable patient that is having had no considerable event (cardiovascular problem, infection, surgical operation) with the exception of angioplasty of fistula or prosthesis vascular, in the previous 3 months the entrance to the study
• Patient capable of understanding and of following the essay, in particular knowing how to read the note of information.

You may not qualify if:

• Pregnant woman
• Treatment by corticoids or immunosuppresseurs
• hemopathy sly
• chronic cancer or infection in evolution

Sponsors & Collaborators

• Assistance Publique Hopitaux De Marseille: lead

Study Sites (1)

Hopital de la Conception- Service de Néphrologie et de transplantation rénale

Marseille, 13385, France

Location

MeSH Terms

Conditions

Renal Insufficiency, Chronic

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Bertrand DUSSOL, MD

  Assistance Publique des Hopitaux de Marseille

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 21, 2008
• First Posted: May 26, 2008
• Study Start: June 1, 2008
• Primary Completion: April 1, 2012
• Study Completion: April 1, 2012
• Last Updated: August 28, 2014

Record last verified: 2014-08

Locations

FR (1)