Body Composition & REE Responses to Bariatric Surgery

NCT00682058 | Completed DMC

• 2 other identifiers: AAAO1655R01DK072507
• Study Type: observational
• Target: 106
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to measure important components of weight change in patients who underwent bariatric surgery on measures of fat mass and its distribution and fat-free mass (FFM) (bone mineral density, skeletal muscle, and specific organs) at 60 months (T60) and 84 months (T84) post-surgery, and to compare compartment sizes with stable weight controls.

Conditions

Weight Loss; Weight Change

Keywords

body composition; weight loss; fat; fat distribution; fat free mass; organ; resting energy expenditure

Outcome Measures

Primary Outcomes (1)

• Fat and fat-free mass

  Approximately 60 months and 84 months post-bariatric surgery

Secondary Outcomes (1)

• Adipose tissue distribution

  Approximately 60 months and 84 months post-bariatric surgery

Other Outcomes (1)

• Resting energy expenditure

  Approximately 60 months and 84 months post-bariatric surgery

Study Arms (1)

LABS patients

Bariatric surgery patients with 35\>BMI kg/m2\<60 prior to surgery will undergo follow-up post-bariatric surgery.

Other: Follow-up post-bariatric surgery

Interventions

Follow-up post-bariatric surgery OTHER

Follow-up of those subjects who had bariatric surgery (as part of the parent LABS trial) immediately following the collection of baseline measures (body composition) in this study. Follow-up body composition measures will be acquired at 60 months and 84 months post-baseline measures (post-surgery).

Also known as: Observational at this time with no intervention

LABS patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who consented and enrolled in the ancillary study, LABS, prior to having bariatric surgery; all came from Weill Cornell and the University of Pittsburgh LABS sites

* Had to have been enrolled in the ancillary study prior to having bariatric surgery * Are able to come to the laboratory for testing.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• Columbia University: lead
• National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): collaborator
• University of Pittsburgh: collaborator

Study Sites (1)

Columbia University Medical Center

New York, New York, 10032, United States

Location

Related Publications (1)

• Ashby-Thompson M, Heshka S, Rizkalla B, Zurlo R, Lemos T, Janumala I, Goodpaster B, DeLany J, Courcoulas A, Strain G, Pomp A, Kang P, Lin S, Thornton J, Gallagher D. Validity of dual-energy x-ray absorptiometry for estimation of visceral adipose tissue and visceral adipose tissue change after surgery-induced weight loss in women with severe obesity. Obesity (Silver Spring). 2022 May;30(5):1057-1065. doi: 10.1002/oby.23415. Epub 2022 Apr 6.

  PMID: 35384351 DERIVED

MeSH Terms

Conditions

Weight Loss; Body Weight Changes; Platelet Glycoprotein IV Deficiency

Condition Hierarchy (Ancestors)

Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• James Delany, PhD

  University of Pittsburgh

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor of Nutritional Medicine

Study Record Dates

• First Submitted: May 20, 2008
• First Posted: May 22, 2008
• Study Start: October 1, 2006
• Primary Completion: January 1, 2018
• Study Completion: June 1, 2018
• Last Updated: February 1, 2019

Record last verified: 2019-01

Locations

US (1)