OPtimal Type 2 dIabetes Management Including Benchmarking and Standard trEatment.
Optimise
1 other identifier
observational
4,027
6 countries
252
Brief Summary
Demonstrate that the use of benchmarking improves quality of patient care, in particular the control of diabetes, lipids and blood pressure, by determining the percentage of patients in the benchmarking group achieving pre-set targets for HbA1c 14,18, LDL-cholesterol16,18 and Systolic Blood Pressure17,18 versus control group (non-benchmarking group) after 12 months of follow-up.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Mar 2008
252 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2008
CompletedFirst Submitted
Initial submission to the registry
May 19, 2008
CompletedFirst Posted
Study publicly available on registry
May 21, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2010
CompletedStudy Completion
Last participant's last visit for all outcomes
January 1, 2010
CompletedJanuary 22, 2020
June 1, 2010
1.8 years
May 19, 2008
January 21, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
HbA1c, LDL-cholesterol, Systolic Blood Pressure
Visit 1; Visit 2 (after approximately 4 months after visit 1); Visit 3 (after approximately 8 months after visit 1); Visit 4 (after approximately 12 months after visit 1)
Secondary Outcomes (1)
Glycaemia, Triglycerides, Total and HDL-Cholesterol, Diastolic Blood Pressure, Waist circumference, Smoking habits, Microalbuminuria, Body Mass Index, Physical activity (Rating scale and step counter), Degree of ophthalmic control and dietary advice
Visit 1Visit 2 (after approximately 4 months after visit 1)Visit 3 (after approximately 8 months after visit 1)Visit 4 (after approximately 12 months after visit 1)
Study Arms (2)
1
Control group
2
Benchmarking group
Eligibility Criteria
General Practioners
You may qualify if:
- Provision of informed Consent
- Patients suffering from diabetes type II, insulin dependent or not insulin dependent.
You may not qualify if:
- Type I diabetes
- Pregnancy diabetes
- Hospitalisation, as this is a primary care study
- Patients who are member of the Belgian Diabetes Convention
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- AstraZenecalead
Study Sites (252)
Research Site
Aalst, Belgium
Research Site
Aarschot, Belgium
Research Site
Alsemberg, Belgium
Research Site
Amay, Belgium
Research Site
Antoing, Belgium
Research Site
Antwerp, Belgium
Research Site
Anzegem, Belgium
Research Site
Ath, Belgium
Research Site
Baisy-Thy, Belgium
Research Site
Balleul, Belgium
Research Site
Bastogne, Belgium
Research Site
Battice, Belgium
Research Site
Beerse, Belgium
Research Site
Bellaire, Belgium
Research Site
Bertogne, Belgium
Research Site
Betekom, Belgium
Research Site
Beveren, Belgium
Research Site
Bilzen, Belgium
Research Site
Binche, Belgium
Research Site
Boezinge, Belgium
Research Site
Boirs, Belgium
Research Site
Borgerhout, Belgium
Research Site
Bouillon, Belgium
Research Site
Brain-l'alleud, Belgium
Research Site
Bruges, Belgium
Research Site
Brussels, Belgium
Research Site
Cercxhe-heuseux, Belgium
Research Site
Champion, Belgium
Research Site
Clabeoq, Belgium
Research Site
Corbion, Belgium
Research Site
De Pinte, Belgium
Research Site
Diest, Belgium
Research Site
Dottignies, Belgium
Research Site
Dworp, Belgium
Research Site
Ekeren, Belgium
Research Site
Enghien, Belgium
Research Site
Erembodegem, Belgium
Research Site
Essen, Belgium
Research Site
Eupen, Belgium
Research Site
Geel, Belgium
Research Site
Genk, Belgium
Research Site
Genly, Belgium
Research Site
Geraardsbergen, Belgium
Research Site
Ghent, Belgium
Research Site
Ghlin, Belgium
Research Site
Gilly, Belgium
Research Site
Gozée, Belgium
Research Site
Gribomont, Belgium
Research Site
Haaltert, Belgium
Research Site
Halen, Belgium
Research Site
Halle, Belgium
Research Site
Ham, Belgium
Research Site
Hannut, Belgium
Research Site
Hasselt, Belgium
Research Site
Havinnes, Belgium
Research Site
Havré, Belgium
Research Site
Herent, Belgium
Research Site
Herstal, Belgium
Research Site
Herzele, Belgium
Research Site
Hoboken, Belgium
Research Site
Hooglede, Belgium
Research Site
Houthalen-Helchteren, Belgium
Research Site
Incourt, Belgium
Research Site
Jemappes, Belgium
Research Site
Kapellen, Belgium
Research Site
Knokke, Belgium
Research Site
Kuringen, Belgium
Research Site
La Hulpe, Belgium
Research Site
La Louvière, Belgium
Research Site
La Roche, Belgium
Research Site
Laakdal, Belgium
Research Site
Lanaken, Belgium
Research Site
Lauwe, Belgium
Research Site
Lessines, Belgium
Research Site
Libramont, Belgium
Research Site
Lier, Belgium
Research Site
Liège, Belgium
Research Site
Ligne, Belgium
Research Site
Ligney, Belgium
Research Site
Linkebeek, Belgium
Research Site
Lo-reninge, Belgium
Research Site
Louveigné, Belgium
Research Site
Manage, Belgium
Research Site
Marche, Belgium
Research Site
Marchin, Belgium
Research Site
Marchovelette, Belgium
Research Site
Marloie, Belgium
Research Site
Mechelen, Belgium
Research Site
Merksem, Belgium
Research Site
Merksplas, Belgium
Research Site
Mettet, Belgium
Research Site
Moerkerke, Belgium
Research Site
Mol, Belgium
Research Site
Moorlede, Belgium
Research Site
Moorsel, Belgium
Research Site
Mouscron, Belgium
Research Site
Noorderwijk, Belgium
Research Site
Olen, Belgium
Research Site
Ooigem, Belgium
Research Site
Oostrozebeke, Belgium
Research Site
Oppuurs, Belgium
Research Site
Ostend, Belgium
Research Site
Outer, Belgium
Research Site
Perk, Belgium
Research Site
Pittem, Belgium
Research Site
Poederlee, Belgium
Research Site
Poelkapelle, Belgium
Research Site
Quaregnon, Belgium
Research Site
Rance, Belgium
Research Site
Ransart, Belgium
Research Site
Retie, Belgium
Research Site
Retinne, Belgium
Research Site
Roeselare, Belgium
Research Site
Ronse, Belgium
Research Site
Rotheux-Rimière, Belgium
Research Site
Ruiselede, Belgium
Research Site
Saint-Vaast, Belgium
Research Site
Saintes, Belgium
Research Site
Saive, Belgium
Research Site
Schilde, Belgium
Research Site
Selayn, Belgium
Research Site
Sint-Lambrechts-Herk, Belgium
Research Site
Sint-Niklaas, Belgium
Research Site
Staden, Belgium
Research Site
Steenokkerzeel, Belgium
Research Site
Templeuve, Belgium
Research Site
Tessenderlo, Belgium
Research Site
Thuin, Belgium
Research Site
Tielt, Belgium
Research Site
Tubize, Belgium
Research Site
Veurne, Belgium
Research Site
Vosselaar, Belgium
Research Site
Waasmunster, Belgium
Research Site
Wanze, Belgium
Research Site
Waremme, Belgium
Research Site
Wasseiges, Belgium
Research Site
Watervliet, Belgium
Research Site
Wellin, Belgium
Research Site
Wenduine, Belgium
Research Site
Wervik, Belgium
Research Site
Westrozebeke, Belgium
Research Site
Wetteren, Belgium
Research Site
Willebroek, Belgium
Research Site
Wingene, Belgium
Research Site
Zedelgem, Belgium
Research Site
Zemst, Belgium
Research Site
Zoersel, Belgium
Research Site
Zonnebeke, Belgium
Research Site
Zottegem, Belgium
Research Site
Zwevegem, Belgium
Research Site
Crete, Crete, Greece
Research Site
Corfu, Kerkyra, Greece
Research Site
Lakonia, Lakonia, Greece
Research Site
Piraeus, Peiraias, Greece
Research Site
Agrinio, Greece
Research Site
Alexandroupoli, Greece
Research Site
Amaliáda, Greece
Research Site
Arta, Greece
Research Site
Athens, Greece
Research Site
Chalcis, Greece
Research Site
Drama, Greece
Research Site
Edessa, Greece
Research Site
Giannitsá, Greece
Research Site
Grevená, Greece
Research Site
Ioannina, Greece
Research Site
Kastoria, Greece
Research Site
Kavala, Greece
Research Site
Komotini, Greece
Research Site
Kos, Greece
Research Site
Kozani, Greece
Research Site
Lamia, Greece
Research Site
Larissa, Greece
Research Site
Náousa, Greece
Research Site
Pátrai, Greece
Research Site
Rhodes, Greece
Research Site
Serres, Greece
Research Site
Thessaloniki, Greece
Research Site
Thérmo, Greece
Research Site
Volos, Greece
Research Site
Bertrange, Luxembourg
Research Site
Bissen, Luxembourg
Research Site
Bridel, Luxembourg
Research Site
Diekierch, Luxembourg
Research Site
Differdange, Luxembourg
Research Site
Dudelange, Luxembourg
Research Site
Esch-sur-Alzette, Luxembourg
Research Site
Ettelbruck, Luxembourg
Research Site
Hollenfels, Luxembourg
Research Site
Hosingen, Luxembourg
Research Site
Kehlen, Luxembourg
Research Site
Larochette, Luxembourg
Research Site
Luxembourg, Luxembourg
Research Site
Obercorn, Luxembourg
Research Site
Redange, Luxembourg
Research Site
Rodange, Luxembourg
Research Site
Rumelange, Luxembourg
Research Site
Sanem, Luxembourg
Research Site
Strassen, Luxembourg
Research Site
Beja, Portugal
Research Site
Elvas, Portugal
Research Site
Faro, Portugal
Research Site
Gaia, Portugal
Research Site
Lisbon, Portugal
Research Site
Penafiel, Portugal
Research Site
Porto, Portugal
Research Site
Santarém, Portugal
Research Site
Torres Novas, Portugal
Research Site
Torres Vedras, Portugal
Research Site
Viana do Castelo, Portugal
Research Site
Barcelona, Barceloan, Spain
Research Site
Sant Fruitós de Bages, Barceloan, Spain
Research Site
Badalona, Barcelona, Spain
Research Site
Manresa, Barcelona, Spain
Research Site
Monistrol de Montserrat, Barcelona, Spain
Research Site
Begonte, Lugo, Spain
Research Site
Guitiriz, Lugo, Spain
Research Site
Viveiro, Lugo, Spain
Research Site
San Fernando de Henares, Madrid, Spain
Research Site
Ribadesella, Principality of Asturias, Spain
Research Site
Villar del Arzobispo, Valencia, Spain
Research Site
Mombuey, Zamora, Spain
Research Site
Tábara, Zamora, Spain
Research Site
Letux, Zaragoza, Spain
Research Site
A Coruña, Spain
Research Site
Lugo, Spain
Research Site
Madrid, Spain
Research Site
Valencia, Spain
Research Site
Zaragoza, Spain
Research Site
Aldershot, United Kingdom
Research Site
Atherstone, United Kingdom
Research Site
Belfast, United Kingdom
Research Site
Blackburn, United Kingdom
Research Site
Bolton, United Kingdom
Research Site
Bradford, United Kingdom
Research Site
Cardiff, United Kingdom
Research Site
Coventry, United Kingdom
Research Site
Crawley, United Kingdom
Research Site
Crowthorne, United Kingdom
Research Site
Doncaster, United Kingdom
Research Site
Glasgow, United Kingdom
Research Site
Harrow, United Kingdom
Research Site
High Valleyfield, United Kingdom
Research Site
Peterborough, United Kingdom
Research Site
Royal Leamington Spa, United Kingdom
Research Site
Slough, United Kingdom
Research Site
Sneinton, United Kingdom
Research Site
Stevenage, United Kingdom
Research Site
Sunbury-on-Thames, United Kingdom
Research Site
Sutton, United Kingdom
Research Site
Watford, United Kingdom
Research Site
Wellingborough, United Kingdom
Research Site
Westbury, United Kingdom
Related Publications (5)
Tsimihodimos V, Kostapanos MS, Moulis A, Nikas N, Elisaf MS. Effects of benchmarking on the quality of type 2 diabetes care: results of the OPTIMISE (Optimal Type 2 Diabetes Management Including Benchmarking and Standard Treatment) study in Greece. Ther Adv Endocrinol Metab. 2015 Oct;6(5):199-209. doi: 10.1177/2042018815592803.
PMID: 26445642DERIVEDHermans MP, Elisaf M, Michel G, Muls E, Nobels F, Vandenberghe H, Brotons C; OPTIMISE International Steering Committee. Benchmarking is associated with improved quality of care in type 2 diabetes: the OPTIMISE randomized, controlled trial. Diabetes Care. 2013 Nov;36(11):3388-95. doi: 10.2337/dc12-1853. Epub 2013 Jul 11.
PMID: 23846810DERIVEDMichel G; OPTIMISE. [The OPTIMISE study (Optimal Type 2 Diabetes Management Including Benchmarking and Standard Treatment]. Results for Luxembourg]. Bull Soc Sci Med Grand Duche Luxemb. 2012;(1):43-9. French.
PMID: 22822562DERIVEDHermans MP, Brotons C, Elisaf M, Michel G, Muls E, Nobels F; (for the OPTIMISE (OPtimal Type 2 dIabetes Management Including benchmarking and Standard trEatment) International Steering Committee). Optimal type 2 diabetes mellitus management: the randomised controlled OPTIMISE benchmarking study: baseline results from six European countries. Eur J Prev Cardiol. 2013 Dec;20(6):1095-105. doi: 10.1177/2047487312449414. Epub 2012 May 17.
PMID: 22605788DERIVEDNobels F, Debacker N, Brotons C, Elisaf M, Hermans MP, Michel G, Muls E; OPTIMISE (OPtimal Type 2 dIabetes Management Including benchmarking and Standard trEatment) International Steering Committee. Study rationale and design of OPTIMISE, a randomised controlled trial on the effect of benchmarking on quality of care in type 2 diabetes mellitus. Cardiovasc Diabetol. 2011 Sep 22;10:82. doi: 10.1186/1475-2840-10-82.
PMID: 21939502DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Hermans, M. Prof.
UCL
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- INDUSTRY
Study Record Dates
First Submitted
May 19, 2008
First Posted
May 21, 2008
Study Start
March 1, 2008
Primary Completion
January 1, 2010
Study Completion
January 1, 2010
Last Updated
January 22, 2020
Record last verified: 2010-06