Circulating Endothelium Progenitor Cells and Endogenous Oestrogen in Healthy Subjects
Oestropec
Impact of Endogenous Sexual Hormones (Oestrogens and Testosterone) on the Endothelium Circulatory on Rolling at the Young and Old Healthy Volunteer.
1 other identifier
observational
48
1 country
1
Brief Summary
The purpose of this study is to determine whether the number of circulating EPC is different between healthy women and men.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Apr 2006
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2006
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2007
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2007
CompletedFirst Submitted
Initial submission to the registry
April 9, 2008
CompletedFirst Posted
Study publicly available on registry
April 29, 2008
CompletedApril 29, 2008
March 1, 2006
1 year
April 9, 2008
April 28, 2008
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Number of endothelial progenitor cells by cytometry
Baseline
Secondary Outcomes (1)
To compare the number of EPC in young women to older men and menopausal women. To evaluate the correlation between the number of EPC and 17 b-estradiol plasma level.
Baseline
Study Arms (4)
1
Non menopausal women
2
age matched men
3
Menopausal women
4
age matched men
Eligibility Criteria
Healthy volunteers
You may qualify if:
- BMI between 19 and 25 kg/m²
- non menopausal women :
- age 18 to 40 years,
- regular menstrual cycles
- no hormone therapy as contraceptives
- postmenopausal women :
- age above 55 years old
- amenorrhoea since 5 years at least
- no hormone therapy since at least 3 month
You may not qualify if:
- no medical insurance
- smoking, Statins treatment, uncontrolled diabetes or hypertension and personal history of cardiovascular disease.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Assistance Publique Hopitaux de Paris - Hopital Saint Antoine
Paris, 75012, France
Biospecimen
whole peripheral blood (150 ml)
Study Officials
- PRINCIPAL INVESTIGATOR
Tabassome Simon, MD - PhD
Assistance Publique Hopitaux de Paris - Université Pierre et Marie Curie Paris 6
Study Design
- Study Type
- observational
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
April 9, 2008
First Posted
April 29, 2008
Study Start
April 1, 2006
Primary Completion
April 1, 2007
Study Completion
April 1, 2007
Last Updated
April 29, 2008
Record last verified: 2006-03