Facial Expression Recognition of Emotion and Categorization of Emotional Words in Gilles de la Tourette's Syndrome

NCT00664300 | Completed

• 2 other identifiers: CHU-0032RBHP 2007 Jalenques
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Gilles de la Tourette's syndrome is a childhood onset inherited neuropsychiatric disorder characterised by the presence of both multiple motor tics and one or more vocal tics (noises), with psychiatric and/or behaviour disorders (such as obsessive compulsive behaviour…). This disease is associated with an dopamine system imbalance which could be responsible of a specific trouble in the recognition in some facial expression. This has been already shown in Gilles de la Tourette patients with obsessive compulsive behaviour. We hypothesise that patients with Gilles de la Tourette's syndrome present a dysfunction of voluntary and automatic treatment of emotional information. The main purpose of this study is to show if patients with Gilles de la Tourette's syndrome present a lack of specific facial expression recognition of emotion and determinate more precisely if this alteration involves the cortical way (high frequency way) or the under cortical way (low frequency way).

Conditions

Gilles de la Tourette's Syndrome

Keywords

Gilles de la Tourette's syndrome; Facial expression recognition of emotion; Frequency levels; Automatic and voluntary information treatment; Patient with Gilles de la Tourette's syndrome

Outcome Measures

Primary Outcomes (1)

• Facial expression recognition test

  % of exact responses

Secondary Outcomes (1)

• Lexical decision test

  The time to respond

Study Arms (1)

2

One group with Gilles de la Tourette's Syndrome One group with healthy paired volunteers

Behavioral: Facial expression recognition of emotion

Interventions

Facial expression recognition of emotion BEHAVIORAL

Facial expression recognition test Lexical decision test

2

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

30 patients with Gilles de la Tourette's Syndrome and 30 healthy paired volunteers (control group)

You may qualify if:

• Age : \>18 years
• Patient with a Gilles de la Tourette 's syndrome such as defined in the DSMIV
• Stability of treatment \>1 month
• Mini Mental State \> 26
• Affiliation to social security
• Agreement of patients

You may not qualify if:

• Patients with cognitive disorders, dementia, mental retardation…
• Patients with serious neurological pathologies
• Patients with a vision contrast altered.
• Patients who do not understand the words associated with an emotion
• Pregnant women
• Person who participate to an other study

Sponsors & Collaborators

• University Hospital, Clermont-Ferrand: lead

Study Sites (1)

CHU

Clermont-Ferrand, 63003, France

Location

MeSH Terms

Conditions

Tourette Syndrome

Condition Hierarchy (Ancestors)

Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tic Disorders; Movement Disorders; Heredodegenerative Disorders, Nervous System; Neurodegenerative Diseases; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neurodevelopmental Disorders; Mental Disorders

Study Officials

• Isabelle Jalenques, PUPH

  University Hospital, Clermont-Ferrand

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: April 21, 2008
• First Posted: April 22, 2008
• Study Start: August 1, 2007
• Primary Completion: October 1, 2008
• Study Completion: October 1, 2009
• Last Updated: January 19, 2011

Record last verified: 2011-01

Locations

FR (1)