Arm Training in Patients With Chronic Obstructive Pulmonary Disease

NCT00657293 | Completed

• 1 other identifier: Goldstein_Arm1207
• Study Type: interventional
• Target: 34
• Locations: 1 country
• Sites: 1

Brief Summary

Patients with chronic lung disease often report shortness of breath when they use their arms for simple activities of daily living such as dressing, lifting, shaving, bathing and brushing their hair and teeth. The best type of arm training for these patients is still unknown. The objectives of this study are to:

• develop a feasible and safe arm training program (ATP) for these patients;
• examine the effects of this ATP on quality of life, arm function, arm exercise capacity and symptoms during activities of daily living;
• examine the effects of ATP on breathing responses during arm exercises.

Conditions

Chronic Obstructive Pulmonary Disease

Keywords

COPD; arm training; dyspnoea; quality of life

Outcome Measures

Primary Outcomes (1)

• Feasibility measures, dyspnoea during activities of daily living, fatigue, health-related quality of life, unsupported arm exercise capacity, arm function and peripheral muscle force

  Primary outcome measures will be collected before PR program, on completion of the PR program (at 6 weeks) and at three months following completion of the PR program.

Secondary Outcomes (1)

• Peak cardiorespiratory responses during incremental unsupported upper limb exercise test

  Secondary outcome measures will be collected before PR program, on completion of the PR program (at 6 weeks) and at three months following completion of the PR program.

Study Arms (2)

C

SHAM COMPARATOR

In an attempt to make the groups comparable in terms of attention, the control group will receive a sham.

Behavioral: Purdue pegboard test (sham)

ATP

ACTIVE COMPARATOR

Patients will undergo a specific arm training program (ATP).

Behavioral: Arm training program

Interventions

Arm training program BEHAVIORAL

Patients will undergo a specific arm training program (ATP) three times a week for the duration of the 6 week program. The ATP will consist predominantly of resistance exercises. Muscle groups targeted during the ATP will include deltoid, biceps and triceps, pectoralis and latissimus. Subjects will train using multi station gym equipment and free weights.

ATP

Purdue pegboard test (sham) BEHAVIORAL

In an attempt to make the groups comparable in terms of attention, the control group will perform the purdue pegboard test of finger dexterity. The tasks will be performed in a sitting position with the arms supported on a table. This test will consist of 4 timed tasks where as many pins as possible will be placed on a pegboard in a given time. Performance of the pegboard test is likely to improve with practice which may serve to motivate the patients to continue practicing over the 6-week period. Subjects will perform this activity 3 times per week with supervision provided by a physiotherapist.

C

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• a diagnosis of COPD
• a forced expiratory volume in one second (FEV1) of less than 80% the predicted normal value
• must report dyspnoea during at least one activity of daily living that requires arm activity
• must have a smoking history greater than 10 pack years and
• must be able to provide written informed consent

You may not qualify if:

• acute exacerbation of COPD that required a change in pharmacological management within the preceding two months
• an inability to understand English
• cognitive impairment
• requirement for mechanical ventilation for all or part of the day
• tapering doses of oral corticosteroids or xanthines
• evidence of a musculoskeletal or neurological condition which could adversely affect arm exercise performance
• symptomatic ischemic cardiac disease
• a history of previous lung surgery and alpha1 antitrypsin deficient emphysema

Sponsors & Collaborators

• West Park Healthcare Centre: lead

Study Sites (1)

West Park Healthcare Centre

Toronto, Ontario, M6M 2J5, Canada

Location

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive; Dyspnea

Interventions

salicylhydroxamic acid

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Respiration Disorders; Signs and Symptoms, Respiratory; Signs and Symptoms

Study Officials

• Roger Goldstein, M.D.

  West Park Healthcare Centre

  PRINCIPAL INVESTIGATOR

• Dina Brooks, Ph.D.

  West Park Healthcare Centre

  PRINCIPAL INVESTIGATOR

• Tania Janaudis-Ferreira, Msc

  West Park Healthcare Centre

  STUDY CHAIR

• Kylie Hill, Ph.D.

  West Park Healthcare Centre

  STUDY CHAIR

• Tom Dolmage, Msc

  West Park Healthcare Centre

  STUDY CHAIR

• Marla Beauchamp, Msc

  West Park Healthcare Centre

  STUDY CHAIR

• Karin Wadell, Ph.D.

  Umea University

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: April 8, 2008
• First Posted: April 14, 2008
• Study Start: July 1, 2008
• Primary Completion: January 1, 2010
• Study Completion: January 1, 2010
• Last Updated: February 22, 2010

Record last verified: 2010-02

Locations

CA (1)