Randomized, Double-Blind, Multicenter, Trial to Assess the Effect of High & Low Doses of ZD4522 on Progression of Carotid Artery Atheroma in Moderately Hypercholesterolemic Subjects With Asymptomatic Carotid Stenosis After 24 Months of Dosing.
Sponsor study identifier
Secondary identifiers
interventional
200
0 countries
N/A
Study Start
January 2000
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
Not reported
Date not reportedStudy Completion
August 2004
Actual (reported)The purpose of this study is to examine the changes in the carotid artery when subjects receive high or low doses of rosuvastatin.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
August 2004
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 2000
Date type not reportedThis date has not been verified as actual or estimated.
August 2004
Actual (reported)April 3, 2008
Actual (reported)April 8, 2008
Actual (reported)Changes in carotid wall volume as measured by MRI scan
At 40 weeks and 104 weeks
Safety: adverse events & abnormal laboratory markers
2 weekly for first 4 weeks then 4 weekly
Other changes in the structure and composition of the carotid arterial wall as defined in the protocol.
At 40 weeks and 104 weeks
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Clezar CN, Flumignan CD, Cassola N, Nakano LC, Trevisani VF, Flumignan RL. Pharmacological interventions for asymptomatic carotid stenosis. Cochrane Database Syst Rev. 2023 Aug 4;8(8):CD013573. doi: 10.1002/14651858.CD013573.pub2.
Tom Hatsukami
University of Washington, USA
Russell Esterline
AstraZeneca
First Submitted
April 3, 2008
First Posted
April 8, 2008
Study Start
January 2000
Date type not reportedThis date has not been verified as actual or estimated.
Study Completion
August 2004
Actual (reported)Direct Statin Comparison of LDL-C Values: an Evaluation of Rosuvastatin Therapy
Contact the study team to confirm eligibility.
Last Updated
March 16, 2009
Record last verified: 2009-03
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
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