Effects of Whole-Body Vibration Exercise on Serum IGF-1 in Fibromyalgia

NCT00650715 | Completed

• 1 other identifier: WBVIGF1FM
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study was to investigate the acute and chronic effect of whole-body vibration exercise on serum insulin-like growth factor-1 levels in women with fibromyalgia (FM). It was hypothesized that women with FM would exhibit an increase in IGF-1 following both acute and chronic WBV. Twenty-four women with FM were randomized into two groups: Vibration Group (VG) and Control Group (CG). The VG underwent a protocol with WBV exercise twice a week for a total of six weeks, whereas the CG performed the same protocol without vibratory stimulus. Both groups continued with their usual pharmacological treatment. Serum IGF-1 levels were determined using Enzyme-Linked Immunosorbent Assay (ELISA). To test the effect of chronic WBV, serum IGF-1 measurements were taken at baseline and at weeks 1,3, and 6 of intervention. To test the effect of acute WBV, within week 1, serum IGF-1 measurements were taken before and immediately following a session of WBV.

Conditions

Fibromyalgia; Hormonal Responses to Exercise in Patients With Fibromyalgia.

Keywords

Fibromyalgia; Whole-Body vibration; Exercise; IGF-1

Outcome Measures

Primary Outcomes (1)

• Serum IGF-1 levels

  Baseline, Week 1, Week 3, Week 6

Study Arms (2)

VG

ACTIVE COMPARATOR

Vibration Group (VG) underwent a protocol with whole-body vibration exercise twice a week for a total of six weeks. The group continued with their usual pharmacological treatment.

Device: Vibratory platform, PowerPlate®, Badhoevendorp, Netherlands

CG

PLACEBO COMPARATOR

The Control Group (CG) underwent the same protocol of exercises than VG but without vibratory stimulus. The CG continued with their usual pharmacological treatment.

Device: Placebo Whole-body vibration exercise

Interventions

Vibratory platform, PowerPlate®, Badhoevendorp, Netherlands DEVICE

Six exercises (static and dynamic tasks) while standing on a Whole-body vibration platform. The six exercises (30 seconds each) were repeated six times with a recovery of 3 minutes in between. The Whole-body vibration intensity was kept constant at 30 Hz of frequency and 2 mm of amplitude.

VG

Placebo Whole-body vibration exercise DEVICE

Six exercises (static and dynamic tasks) while standing on a Whole-body vibration platform. The six exercises (30 seconds each) were repeated six times with a recovery of 3 minutes in between. All exercises were performed without the influence of a vibratory stimulus.

CG

Eligibility Criteria

• Age: 35 Years - 69 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients diagnosed of fibromyalgia according to the American College of Rheumatology criteria for at least three years.

You may not qualify if:

• Orthopedic limitation, or cardiovascular, pulmonary, or metabolic disease that would preclude exercise.
• Participation in any other study.

Sponsors & Collaborators

• Institut Nacional d'Educacio Fisica de Catalunya: lead

Study Sites (1)

Institut Nacional d'Educación Física de Catalunya

Barcelona, Barcelona, 08038, Spain

Location

MeSH Terms

Conditions

Fibromyalgia; Motor Activity

Condition Hierarchy (Ancestors)

Muscular Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Neuromuscular Diseases; Nervous System Diseases; Behavior

Study Officials

• Eduard Alentorn-Geli, MD

  INEFC

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: March 31, 2008
• First Posted: April 2, 2008
• Study Start: December 1, 2004
• Primary Completion: January 1, 2005
• Study Completion: January 1, 2005
• Last Updated: April 2, 2008

Record last verified: 2008-03

Locations

ES (1)