Inflammatory Breast Cancer, Tumor Markers, and Factors Associated With Angiogenesis

NCT00646555 | Completed

• 2 other identifiers: 99990405104-C-N051
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

This study, conducted by the NCI and the George Washington University Medical Center (GWUMC), will examine breast tissue from patients with inflammatory breast cancer (IBC) for tumor markers and factors associated with angiogenesis. Angiogenesis is the formation of new blood vessels that is essential for tumor growth and spread. IBC is an extremely rare, aggressive form of breast cancer that disproportionately affects young women. The risk factors for IBC, its cause, and how it develops are unknown, but the disease appears to involve a high degree of angiogenesis. Tissue specimens for this study will be obtained from GWUMC's Inflammatory Breast Cancer Registry and Biospecimen Repository. The registry was established to develop a national registry of patients with IBC that includes standardized clinical, epidemiological, and pathological information, along with disease recurrence and survival data. For this study, tissue specimens from the repository will be tested for biological markers and angiogenesis parameters to help in the classification of the tumors. Biological markers (such as estrogen receptor, progesterone receptor, the p53 gene, and others) and angiogenesis parameters (such as various proteins involved in vessel formation) will be examined to determine their prevalence in tissue specimens and their relationship to patient survival. When possible, the findings will be compared with non-IBC tissue samples.

Conditions

Breast Neoplasms

Keywords

Tissue Samples; VEGF Receptors; VEGF; Microvessel Density; Hypoxia Inducible Factor; Inflammatory Breast Cancer; IBC

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients with inflammatory breast cancer.
• Age greater than 18 years.

Sponsors & Collaborators

• National Cancer Institute (NCI): lead

Study Sites (1)

GW University Medical Center GW Hospital Center

Washington D.C., District of Columbia, 20037, United States

Location

Related Publications (3)

• Folkman J. Angiogenesis and apoptosis. Semin Cancer Biol. 2003 Apr;13(2):159-67. doi: 10.1016/s1044-579x(02)00133-5.

  PMID: 12654259 BACKGROUND

• Weidner N, Semple JP, Welch WR, Folkman J. Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. N Engl J Med. 1991 Jan 3;324(1):1-8. doi: 10.1056/NEJM199101033240101.

  PMID: 1701519 BACKGROUND

• Gasparini G, Weidner N, Bevilacqua P, Maluta S, Dalla Palma P, Caffo O, Barbareschi M, Boracchi P, Marubini E, Pozza F. Tumor microvessel density, p53 expression, tumor size, and peritumoral lymphatic vessel invasion are relevant prognostic markers in node-negative breast carcinoma. J Clin Oncol. 1994 Mar;12(3):454-66. doi: 10.1200/JCO.1994.12.3.454.

  PMID: 7509851 BACKGROUND

MeSH Terms

Conditions

Breast Neoplasms; Inflammatory Breast Neoplasms

Condition Hierarchy (Ancestors)

Neoplasms by Site; Neoplasms; Breast Diseases; Skin Diseases; Skin and Connective Tissue Diseases

Study Officials

• Amy Subar, Ph.D.

  National Cancer Institute (NCI)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: March 27, 2008
• First Posted: March 28, 2008
• Study Start: November 20, 2003
• Study Completion: April 10, 2012
• Last Updated: July 2, 2017

Record last verified: 2012-04-10

Locations

US (1)