NCT00635271|Terminated
Biomarkers in Exhaled Breath From Asthmatic Patients
Identification of Biomarkers in Exhaled Breath Condensates From Asthmatic Patients
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Identification of Biomarkers in Exhaled Breath Condensates From Asthmatic Patients
Sponsor study identifier
Secondary identifiers
observational
19
1 country
1
Study Start
February 29, 2008
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
Not reported
Date not reportedStudy Completion
November 28, 2012
Date type not reportedThis date has not been verified as actual or estimated.
This study will look for a relationship between asthma and factors released from the lungs in exhaled breath. If a relationship can be established, the identified factors may be used as biomarkers to predict episodes of increased asthma symptoms so that medications can be given to prevent the onset of an asthma attack. Healthy volunteers and people who have had asthma for at least 1 year may be eligible for this study. Candidates must be between 18 and 75 years of age. Participants undergo blood tests and breathing tests. For the latter, participants breathe into a machine before and after inhaling an asthma medication called albuterol. The machine measures the volume of air the subject can breathe out. Participants also provide a sample of exhaled breath by breathing normally for up to 30 minutes while wearing a mask devised for the procedure. Pulse rate, oxygen saturation and wheezing are monitored during the breath collection.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
November 28, 2012
Date type not reportedThis date has not been verified as actual or estimated.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
February 29, 2008
Date type not reportedThis date has not been verified as actual or estimated.
March 8, 2008
Actual (reported)March 13, 2008
Actual (reported)November 28, 2012
Date type not reportedThis date has not been verified as actual or estimated.
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, 20892, United States
Braman SS. The global burden of asthma. Chest. 2006 Jul;130(1 Suppl):4S-12S. doi: 10.1378/chest.130.1_suppl.4S.
El-Ekiaby A, Brianas L, Skowronski ME, Coreno AJ, Galan G, Kaeberlein FJ, Seitz RE, Villaba KD, Dickey-White H, McFadden ER Jr. Impact of race on the severity of acute episodes of asthma and adrenergic responsiveness. Am J Respir Crit Care Med. 2006 Sep 1;174(5):508-13. doi: 10.1164/rccm.200603-431OC. Epub 2006 Jun 8.
Stewart J Levine, M.D.
National Heart, Lung, and Blood Institute (NHLBI)
19 participants (actual enrollment reported by the registry).
First Submitted
March 8, 2008
First Posted
March 13, 2008
Study Start
February 29, 2008
Date type not reportedThis date has not been verified as actual or estimated.
Contact the study team to confirm eligibility.
Wenzel S. Severe asthma in adults. Am J Respir Crit Care Med. 2005 Jul 15;172(2):149-60. doi: 10.1164/rccm.200409-1181PP. Epub 2005 Apr 22.
Study Completion
November 28, 2012
Date type not reportedThis date has not been verified as actual or estimated.
Last Updated
December 5, 2019
Record last verified: 2012-11-28
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Source: ClinicalTrials.gov.
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