Aortic Dimensions in Turner Syndrome

NCT00624949 | Unknown

• 1 other identifier: 20010248
• Study Type: observational
• Target: 102
• Locations: 0 countries
• Sites: N/A

Brief Summary

An observational study of 102 women with Turner syndrome followed for 6 years with a two-yearly examination including ECHO, MRI of the heart and 24 ambulatory blood pressure. It has been found that besides an significantly increased risk of congenital cardiac malformations, TS have an increased risk of developing cardiac disease including the life threatening condition of aortic dilatation and rupture. The aim of the study is to describe the cardiac conditions of TS, evaluate different methods of examination and identify possible risc factors.

Conditions

Turner Syndrome

Keywords

Turner syndrome; aortic dimensions; blood pressure; aortic dilatation; aortic rupture

Outcome Measures

Primary Outcomes (1)

• Aortic diameter at 3 well-defined levels measured by MRI and ECHO

  2-yearly for 6 years

Secondary Outcomes (1)

• 24hour ambulatory blood pressure

  24h 2-yearly for 6 years

Study Arms (2)

1

women with Turner syndrome

2.

Control women

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Recrutted from hospital clinics and through the patient organisation

You may qualify if:

• Turner syndrome
• Age 18-70 years

You may not qualify if:

• Extreme adipositas
• Contraindications to a MRI scan
• Malignant disease

Sponsors & Collaborators

• University of Aarhus: lead

Related Publications (3)

• Viuff M, Skakkebaek A, Johannsen EB, Chang S, Pedersen SB, Lauritsen KM, Pedersen MGB, Trolle C, Just J, Gravholt CH. X chromosome dosage and the genetic impact across human tissues. Genome Med. 2023 Mar 28;15(1):21. doi: 10.1186/s13073-023-01169-4.

  PMID: 36978128 DERIVED

• Trolle C, Mortensen KH, Bjerre M, Hougaard DM, Cohen A, Andersen NH, Gravholt CH. Osteoprotegerin in Turner syndrome - relationship to aortic diameter. Clin Endocrinol (Oxf). 2015 Mar;82(3):397-403. doi: 10.1111/cen.12522. Epub 2014 Jul 2.

  PMID: 24923356 DERIVED

• Trolle C, Mortensen KH, Pedersen LN, Berglund A, Jensen HK, Andersen NH, Gravholt CH. Long QT interval in Turner syndrome--a high prevalence of LQTS gene mutations. PLoS One. 2013 Jul 25;8(7):e69614. doi: 10.1371/journal.pone.0069614. Print 2013.

  PMID: 23936059 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

Blood samples

MeSH Terms

Conditions

Turner Syndrome; Aortic Rupture

Condition Hierarchy (Ancestors)

Gonadal Dysgenesis; Disorders of Sex Development; Urogenital Abnormalities; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Sex Chromosome Disorders of Sex Development; Male Urogenital Diseases; Heart Defects, Congenital; Cardiovascular Abnormalities; Cardiovascular Diseases; Heart Diseases; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Sex Chromosome Disorders; Chromosome Disorders; Genetic Diseases, Inborn; Gonadal Disorders; Endocrine System Diseases; Aneurysm, Ruptured; Aneurysm; Vascular Diseases; Aortic Aneurysm; Aortic Diseases; Rupture; Wounds and Injuries

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: February 19, 2008
• First Posted: February 28, 2008
• Study Start: August 1, 2003
• Primary Completion: June 1, 2012
• Study Completion: June 1, 2012
• Last Updated: February 28, 2008

Record last verified: 2008-02