NCT00619437

Brief Summary

Genetic etiology in schizophrenia is widely accepted. However, many chromosomal sites were shown to characterize the families of patients with schizophrenia. This is probably due to the high genetic heterogenity of this illness. Thus, it is important to investigate the genetic factor in relatively genetically homogenous populations. Many studies have indicate that Ashkenazy Jews show relative gentic homogenity. Indeed, the genes responsible for most Mendelian disorders of Jewish peoples have been identified. The study will apply genome-wide mutation screening methods to identify candidate allells in subjects of Ashkenazi Jewish ancestry with multiplex schizophrenia.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
100

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Apr 2008

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

February 10, 2008

Completed
11 days until next milestone

First Posted

Study publicly available on registry

February 21, 2008

Completed
1 month until next milestone

Study Start

First participant enrolled

April 1, 2008

Completed
1.7 years until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2009

Completed
Last Updated

February 21, 2008

Status Verified

February 1, 2008

First QC Date

February 10, 2008

Last Update Submit

February 10, 2008

Conditions

Schizophrenia

Keywords

schizophreniageneticsfamilymultiplexhaplotypes

Eligibility Criteria

Age18 Years - 78 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

schizophrenia

You may qualify if:

  • Age 18+;
  • Meet DSM-IV criteria for Schizophrenia;
  • At least one first-degree relative who Meet DSM-IV criteria for Schizophrenia;
  • Can sign the informed consent form.

You may not qualify if:

  • Patients suffering from terminal or incurabale disease;
  • Minors, incompetents

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Sheba Medical Center

Tel Litwinsky, Israel

Location

Biospecimen

Retention: SAMPLES WITH DNA

Cell Lines / DNA

MeSH Terms

Conditions

Schizophrenia

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic DisordersMental Disorders

Study Officials

  • Michael Bunzel, MD

    Psychiatric ward, Sheba Medical Center

    STUDY DIRECTOR

Central Study Contacts

Raz Gross, MD, MPH

CONTACT

972 3 530 3962razg@gertner.health.gov.il

Study Design

Study Type
observational
Observational Model
FAMILY BASED
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER GOV

Study Record Dates

First Submitted

February 10, 2008

First Posted

February 21, 2008

Study Start

April 1, 2008

Study Completion

December 1, 2009

Last Updated

February 21, 2008

Record last verified: 2008-02

Locations

IL(1)