Effect of Pulmonary Rehabilitation on Surgical Outcomes in the Cancer Setting
The Efficacy of Pulmonary Rehabilitation in Improving Surgical Eligibility for Lung Resection
2 other identifiers
interventional
75
1 country
1
Brief Summary
The goal of this clinical research study is to see if pulmonary rehabilitation can improve patients' lung function, which would increase their chances of becoming eligible for surgery. The health of pulmonary rehabilitation participants after surgery will also be examined.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for phase_2 lung-cancer
Started Jan 2008
Longer than P75 for phase_2 lung-cancer
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 28, 2008
CompletedStudy Start
First participant enrolled
January 28, 2008
CompletedFirst Posted
Study publicly available on registry
February 20, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2028
ExpectedStudy Completion
Last participant's last visit for all outcomes
September 1, 2028
January 12, 2026
January 1, 2026
20.6 years
January 28, 2008
January 9, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Treatment Success (conversion from ineligible to eligible status for lung resection following Pulmonary rehabilitation (PR))
Baseline and post treatment (following 3-4 weeks of PR)
Secondary Outcomes (1)
Examine health of pulmonary rehabilitation participants after surgery.
2 Years
Study Arms (1)
Pulmonary Rehabilitation
EXPERIMENTALPulmonary Rehabilitation - Rehabilitation treatment given over about 3-4 weeks. Questionnaire regarding quality-of-life that lasts about 30 minutes.
Interventions
Questionnaire regarding quality-of-life that lasts about 30 minutes.
Rehabilitation treatment given over about 3-4 weeks.
Eligibility Criteria
You may qualify if:
- Patients with anatomically resectable lung tumors who are deemed surgically inoperable based on preoperative pulmonary function testing FEV1 \< 80% pred; DLCO \< 80% pred; FEV1ppo \< 40% pred; DLCO ppo \< 40% pred AND VO2 peak \< 60% predicted or \< 15 ml/kg/min.
- Patients deemed surgically inoperable based on poor performance status (ECOG score 2-3)
- Any non-pulmonary co-morbidity must be stable according to institutional guidelines.
You may not qualify if:
- Previously reported severe pulmonary hypertension (pulmonary artery systolic pressure \> 60 as determined by echocardiogram), refractory cor pulmonale (as manifested by right ventricular dilatation or dysfunction by echocardiogram)
- Previously reported exercise-induced syncope, angina, palpitation, arrhythmia, hypotension (drop of 20% of systolic/diastolic from baseline)
- History of severe congestive heart failure (NYHA class 3 and 4) refractory to medical management, (LVEF \< 40% by echocardiogram).
- Bone metastasis
- Active psychiatric illness that could interfere with treatment.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of Texas MD Anderson Cancer Center
Houston, Texas, 77030, United States
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Vickie Shannon, BS,MD
M.D. Anderson Cancer Center
Study Design
- Study Type
- interventional
- Phase
- phase 2
- Allocation
- NA
- Masking
- NONE
- Purpose
- SUPPORTIVE CARE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
January 28, 2008
First Posted
February 20, 2008
Study Start
January 28, 2008
Primary Completion (Estimated)
September 1, 2028
Study Completion (Estimated)
September 1, 2028
Last Updated
January 12, 2026
Record last verified: 2026-01