Physical Activity in the Treatment of Obesity

NCT00615238 | Completed

• 2 other identifiers: DK53907 (completed 2004)R01DK053907
• Study Type: interventional
• Target: 177
• Locations: 1 country
• Sites: 1

Brief Summary

Although exercise is widely regarded as a key component in obesity treatment, few individuals seem able to adhere to exercise programs over time. In response, efforts have focused on developing new approaches to physical activity that may appeal to sedentary overweight persons. For instance, is has been shown that accumulating multiple short bouts of vigorous exercise may enhance both exercise adherence and weight loss in overweight persons. Accumulating moderate-intensity activity throughout the day may offer comparable health and weight benefits as a traditional exercise program. Public health recommendations now include the option of accumulating 30 minutes of moderate-intensity lifestyle activity for health and well-being. While these two options offer a viable alternative to those who dislike or cannot sustain continuous vigorous exercise programs, it is unclear whether the flexibility of accumulating physical activity or the vigorous intensity of the exercise is responsible for improved weight loss and long-term adherence. The goal of this research is to extend our preliminary findings suggesting that moderate intensity lifestyle activity is an important and viable alternative to traditional structured vigorous exercise for obese dieting individuals. The primary specific aim of this project is to compare the effects of three modes of exercise on long-term weight regain. Participants will be 165 overweight men and women who are sedentary, but otherwise healthy. All participants will receive the same 16-week behavioral weight loss program and will be randomized to one of three exercise study conditions: 1) diet-plus-continuous bouts of vigorous aerobic exercise; 2) diet-plus-short bouts of vigorous aerobic exercise accumulated throughout the day; or 3) diet-plus-moderate intensity lifestyle activity accumulated throughout the day. By varying both the intensity and duration of exercise bouts, we can determine which type of exercise is associated with optimal outcomes one year later. Additional questions of interest include:

1. 1.Does mode of exercise influence exercise adherence?
2. 2.Does mode of exercise improve cardiovascular risk profiles similarly in all three conditions?
3. 3.Does mode of exercise influence changes in body composition?
4. 4.Does mode of exercise influence exercise enjoyment and exercise self-efficacy?

Conditions

Obesity

Keywords

overweight, physical activity, body composition, metabolic syndrome

Outcome Measures

Primary Outcomes (1)

• Participants were randomized to one of three diet and exercise study conditions. We were interested in which type of exercise is associated with optimal short- and long-term body composition changes.

  Baseline, Week-16, Week-68

Secondary Outcomes (1)

• Does mode of exercise improve cardiovascular risk profiles similarly in all three conditions?

  Baseline, week-16, week-68

Study Arms (3)

Diet plus continuous bouts

EXPERIMENTAL

diet-plus-continuous bouts of vigorous aerobic exercise

Behavioral: Diet plus continuous bouts

Diet plus short bouts

EXPERIMENTAL

diet-plus-short bouts of vigorous aerobic exercise accumulated throughout the day

Behavioral: Diet plus short bouts

Diet plus moderate lifestyle activity

EXPERIMENTAL

diet-plus-moderate intensity lifestyle activity accumulated throughout the day

Behavioral: Diet plus moderate lifestyle activity

Interventions

Diet plus continuous bouts BEHAVIORAL

Patients consumed a 1200 kcal/d diet and were instructed to perform 4 30-60 minute aerobic workouts per week

Diet plus continuous bouts

Diet plus short bouts BEHAVIORAL

Patients consumed a 1200 kcal/d diet and were instructed to perform short 10 minutes bouts of aerobic exercise 4 times per week

Diet plus short bouts

Diet plus moderate lifestyle activity BEHAVIORAL

Patients consumed a 1200 kcal/d diet and were instructed to accumulate moderate intensity physical activity on most days of the week.

Diet plus moderate lifestyle activity

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

Sponsors & Collaborators

• National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): lead

Study Sites (1)

Johns Hopkins School of Medicine

Baltimore, Maryland, 21224, United States

Location

MeSH Terms

Conditions

Obesity; Overweight; Motor Activity; Metabolic Syndrome

Interventions

Diet

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior; Insulin Resistance; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases

Intervention Hierarchy (Ancestors)

Nutritional Physiological Phenomena; Diet, Food, and Nutrition; Physiological Phenomena

Study Officials

• Jeremey D Walston, MD

  JHU School of Med

  STUDY DIRECTOR

• Susan J Bartlett, PhD

  JHU School of Med

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 12, 2008
• First Posted: February 14, 2008
• Study Start: April 1, 2000
• Primary Completion: March 1, 2004
• Study Completion: May 1, 2004
• Last Updated: September 28, 2017

Record last verified: 2010-03

Locations

US (1)